KLHL12 Antikörper (N-Term)

Produktnummer ABIN2775905

Produktdetails anti-KLHL12 Antikörper

Target: KLHL12 (Kelch-Like 12 (Drosophila) (KLHL12))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Hund, Pferd, Zebrafisch (Danio rerio), Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KLHL12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: EKGKPYVDIQ GLTASTMEIL LDFVYTETVH VTVENVQELL PAACLLQLKG

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against KLHL12. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human KLHL12

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu KLHL12

Target: KLHL12 (Kelch-Like 12 (Drosophila) (KLHL12))

Andere Bezeichnung: KLHL12 (KLHL12 Produkte)

Synonyme: zgc:92570 antikoerper, wu:fi60g03 antikoerper, C3ip1 antikoerper, C3IP1 antikoerper, DKIR antikoerper, hDKIR antikoerper, Ski2 like RNA helicase antikoerper, kelch like family member 12 L homeolog antikoerper, kelch like family member 12 antikoerper, kelch-like family member 12 antikoerper, kelch-like 12 antikoerper, SKIV2L antikoerper, klhl12.L antikoerper, KLHL12 antikoerper, klhl12 antikoerper, Klhl12 antikoerper

Hintergrund: KLHL12 is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4.
Alias Symbols: C3IP1, DKIR, hDKIR
Protein Interaction Partner: PEF1, TBC1D10C, FGD2, SYNE4, CCBE1, TTBK2, RPP25L, GLYCTK, MRPL10, SNX20, C1QTNF2, ZBP1, KLHL12, WDYHV1, PRR13, CARD10, KLHL3, INMT, CUL3, BAG6, VEGFB, UBE2I, SDCBP, PDGFRB, MPP1, FLNA, TAOK2, DGCR6, DROSHA, EZH2, KLHL2, DVL3, UBC, ATXN1, CAND1, DCUN1D1,
Protein Size: 568

Molekulargewicht: 63 kDa

Gen-ID: 59349

NCBI Accession: NM_021633, NP_067646

UniProt: Q53G59