DMP1 Antikörper (N-Term)

Produktnummer ABIN2775904

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-DMP1 Antikörper wird verwendet zum Nachweis von DMP1 in Proben von Human, Maus, Ratte, Hund, Pferd, Kaninchen, Meerschweinchen, Rind (Kuh) und Zebrafisch (Danio rerio). Er wurde validiert für WB.

Kurzübersicht für DMP1 Antikörper (N-Term) (ABIN2775904)

Target: DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))

Reaktivität: Human, Maus, Ratte, Hund, Pferd, Kaninchen, Meerschweinchen, Rind (Kuh), Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DMP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DMP1 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: DMTF1 Antibody - N-terminal region

Sequenz: LRMYDDRNHV GKYTPEEIEK LKELRIKHGN DWATIGAALG RSASSVKDRC

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against DMTF1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DMTF1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP34603-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-DMP1 Antikörper (ABIN2775904)

Tschan, Gullberg, Shan, Torbett, Fey, Tobler: "The hDMP1 tumor suppressor is a new WT1 target in myeloid leukemias." in: Leukemia, Vol. 22, Issue 5, pp. 1087-90, (2008) (PubMed).

Details zu DMP1

Target: DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))

Andere Bezeichnung: DMTF1

Hintergrund:

Background Information: This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 35 % of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: cyclin D binding myb like transcription factor 1

Alternative Symbols: DMP1, DMTF, MRUL, hDMP1

Protein Name: cyclin-D-binding Myb-like transcription factor 1

Molekulargewicht: 84kDa

Gen-ID: 9988

NCBI Accession: NP_066968

UniProt: Q9Y222