PHD1 Antikörper (N-Term)

Produktnummer ABIN2775821

Der Kaninchen Polyklonal anti-PHD1 Antikörper wird verwendet zum Nachweis von PHD1 in Proben von Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Kaninchen und Schwein. Er wurde validiert für WB.

Kurzübersicht für PHD1 Antikörper (N-Term) (ABIN2775821)

Target: PHD1 (EGLN2) (Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Kaninchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PHD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PHD1 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: EGLN2 Antibody - N-terminal region

Sequenz: SAGSGTPRAT ATSTTASPLR DGFGGQDGGE LRPLQSEGAA ALVTKGCQRL

Homologie: Cow: 79%, Dog: 93%, Guinea Pig: 86%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 79%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against EGLN2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human EGLN2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8099493

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu PHD1

Target: PHD1 (EGLN2) (Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2))

Andere Bezeichnung: EGLN2

Hintergrund:

Background Information: The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. EGLN2 encodes an enzyme responsible for this posttranslational modification. Alternative splicing of EGLN2 results in three transcript variants encoding different isoforms.

Gene Name: Egl nine homolog 2 (C. elegans)

Alternative Symbols: EIT6, PHD1, EIT-6, HPH-1, HPH-3, HIFPH1, HIF-PH1

Protein Name: Egl nine homolog 2

Molekulargewicht: 44kDa

Gen-ID: 112398

NCBI Accession: NP_444274

UniProt: Q96KS0

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Cell RedoxHomeostasis