S1PR5 Antikörper (N-Term)

Produktnummer ABIN2775524

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch S1PR5 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Hund, Schwein und Rind (Kuh) und wurde in 1 Publikation erwähnt.

Kurzübersicht für S1PR5 Antikörper (N-Term) (ABIN2775524)

Target: S1PR5 (Sphingosine-1-Phosphate Receptor 5 (S1PR5))

Reaktivität: Human, Maus, Ratte, Hund, Schwein, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser S1PR5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-S1PR5 Antikörper

Bindungsspezifität: N-Term

Sequenz: MESGLLRPAP VSEVIVLHYN YTGKLRGARY QPGAGLRADA VVCLAVCAFI

Homologie: Cow: 80%, Dog: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against EDG8. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human EDG8

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 147 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-S1PR5 Antikörper (ABIN2775524)

Bock, Pfalzgraff, Weindl: "Sphingosine 1-phospate differentially modulates maturation and function of human Langerhans-like cells." in: Journal of dermatological science, Vol. 82, Issue 1, pp. 9-17, (2016) (PubMed).

Details zu S1PR5

Target: S1PR5 (Sphingosine-1-Phosphate Receptor 5 (S1PR5))

Andere Bezeichnung: EDG8

Hintergrund: EDG8 is a receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. It Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). It may play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.
Alias Symbols: Edg-8, S1P5, S1PR5, SPPR-1, SPPR-2, EDG8
Protein Interaction Partner: TP63, GNA12, GNAO1, GNAI1, SGPP1,
Protein Size: 147

Molekulargewicht: 16 kDa

Gen-ID: 53637

NCBI Accession: NM_003339

UniProt: Q9H228