DC-SIGN/CD209 Antikörper (N-Term)

Produktnummer ABIN2775487

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DC-SIGN/CD209 in WB. Er zeigt eine Reaktivität gegenüber Human und Schwein.

Kurzübersicht für DC-SIGN/CD209 Antikörper (N-Term) (ABIN2775487)

Target: DC-SIGN/CD209 (CD209) (CD209)

Reaktivität: Human, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DC-SIGN/CD209 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DC-SIGN/CD209 Antikörper

Bindungsspezifität: N-Term

Sequenz: AGCLGHGPLV LQLLSFTLLA GLLVQVSKVP SSISQEQSRQ DAIYQNLTQL

Homologie: Human: 100%, Pig: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against CD209. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CD209

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 404 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DC-SIGN/CD209

Target: DC-SIGN/CD209 (CD209) (CD209)

Andere Bezeichnung: CD209

Hintergrund: This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332, often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
Alias Symbols: CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, MGC129965
Protein Interaction Partner: VAC14, IKBKE, LSP1, CYLD, LGALS3BP, CEACAM5, CLU, CLEC4M, CD209, ICAM3, ICAM2, ITGAM, CEACAM1, SP1, HCVgp1,
Protein Size: 404

Molekulargewicht: 46 kDa

Gen-ID: 30835

NCBI Accession: NM_021155, NP_066978

UniProt: Q9NNX6