TMEM2 Antikörper (Middle Region)

Produktnummer ABIN2775385

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TMEM2 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Pferd, Schwein und Meerschweinchen.Es wurde in 1 Publikation zitiert.

Kurzübersicht für TMEM2 Antikörper (Middle Region) (ABIN2775385)

Target: TMEM2 (Transmembrane Protein 2 (TMEM2))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Pferd, Schwein, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TMEM2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TMEM2 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: CEMIP2 Antibody - middle region

Sequenz: MLTGLCQGCG TRQVVFTSDP HKSYLPVQFQ SPDKAETQRG DPSVISVNGT

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against TMEM2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TMEM2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP42382-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-TMEM2 Antikörper (ABIN2775385)

Zhu, Xie, Li, Huang, Zhao, Hu, Wang, Gu, Gao, Peng: "TMEM2 inhibits hepatitis B virus infection in HepG2 and HepG2.2.15 cells by activating the JAK-STAT signaling pathway." in: Cell death & disease, Vol. 7, Issue 6, pp. e2239, (2016) (PubMed).

Details zu TMEM2

Target: TMEM2 (Transmembrane Protein 2 (TMEM2))

Andere Bezeichnung: CEMIP2

Hintergrund:

Background Information: This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss.

Gene Name: cell migration inducing hyaluronidase 2

Alternative Symbols: TMEM2

Protein Name: cell surface hyaluronidase

Molekulargewicht: 154 kDa

Gen-ID: 23670

NCBI Accession: NP_037522

UniProt: Q9UHN6