HAAO Antikörper (N-Term)

Produktnummer ABIN2775371

Produktdetails anti-HAAO Antikörper

Target: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Pferd, Kaninchen, Rind (Kuh), Saccharomyces cerevisiae, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HAAO Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: HRDVVIRQGE IFLLPARVPH SPQRFANTVG LVVERRRLET ELDGLRYYVG

Homologie: Cow: 93%, Dog: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 79%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against HAAO. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HAAO

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 286 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu HAAO

Target: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Andere Bezeichnung: HAAO (HAAO Produkte)

Synonyme: Afu2g17450 antikoerper, 0610007K21Rik antikoerper, 0610012J07Rik antikoerper, 3-HAO antikoerper, 3-HAOxase antikoerper, 3HAO antikoerper, zgc:103585 antikoerper, HAO antikoerper, 3-hydroxyanthranilate 3,4-dioxygenase antikoerper, 3-hydroxyanthranilate 3,4-dioxygenase L homeolog antikoerper, SPO1774 antikoerper, CNB05620 antikoerper, AFUA_2G17450 antikoerper, Bcep18194_C7641 antikoerper, Kfla_5491 antikoerper, Micau_4935 antikoerper, RBRH_03005 antikoerper, Krodi_1278 antikoerper, haao antikoerper, HAAO antikoerper, Haao antikoerper, haao.L antikoerper

Hintergrund: 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.
Alias Symbols: 3-HAO, HAO
Protein Interaction Partner: GAD1, BAG3, TERF2IP, POT1, ARHGDIA,
Protein Size: 286

Molekulargewicht: 32 kDa

Gen-ID: 23498

NCBI Accession: NM_012205, NP_036337

UniProt: P46952