Cytokeratin 1 Antikörper (Middle Region)

Produktnummer ABIN2775333

Der Kaninchen Polyklonal Anti-Cytokeratin 1-Antikörper wurde für WB und IHC validiert. Er ist geeignet, Cytokeratin 1 in Proben von Human, Ratte, Kaninchen und Hund zu detektieren.

Kurzübersicht für Cytokeratin 1 Antikörper (Middle Region) (ABIN2775333)

Target: Cytokeratin 1 (KRT1) (Keratin 1 (KRT1))

Reaktivität: Human, Ratte, Kaninchen, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cytokeratin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Cytokeratin 1 Antikörper

Bindungsspezifität: Middle Region

Sequenz: GSYGSGSSSG GYRGGSGGGG GGSSGGRGSG GGSSGGSIGG RGSSSGGVKS

Homologie: Dog: 86%, Human: 100%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against KRT1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human KRT1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 644 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Cytokeratin 1

Target: Cytokeratin 1 (KRT1) (Keratin 1 (KRT1))

Andere Bezeichnung: KRT1

Hintergrund: KRT1 is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma.The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CK1, EHK1, K1, KRT1A, EHK, EPPK, NEPPK
Protein Interaction Partner: MDM2, LGR4, EED, ESR1, ADRB2, PAN2, Iqcb1, Nphp4, Cep290, Nphp1, Invs, GRDX, VCAM1, UBC, ITGA4, FN1, CDH1, APOA1, ALB, MAGOH, EIF4A3, KRT10, KRT9, KRT2, SLC25A5, SHC1, PIK3R2, INPPL1, GRB2, EPS15, CRK, AP2M1, CBL, UBASH3B, NEDD8, CAND1, DCUN1D1, COPS5, CO
Protein Size: 644

Molekulargewicht: 66 kDa

Gen-ID: 3848

NCBI Accession: NM_006121, NP_006112

UniProt: P04264