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IDH3A Antikörper (N-Term)

Der Kaninchen Polyklonal Anti-IDH3A-Antikörper wurde für WB und IHC validiert. Er ist geeignet, IDH3A in Proben von Human, Ratte, Maus, Rind (Kuh), Hund, Pferd, Kaninchen, Meerschweinchen und Zebrafisch (Danio rerio) zu detektieren. Es ist 1 Publikation verfügbar.
Produktnummer ABIN2775312

Kurzübersicht für IDH3A Antikörper (N-Term) (ABIN2775312)

Target

Alle IDH3A Antikörper anzeigen
IDH3A (Isocitrate Dehydrogenase 3 (NAD+) alpha (IDH3A))

Reaktivität

  • 46
  • 32
  • 18
  • 6
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Human, Ratte, Maus, Rind (Kuh), Hund, Pferd, Kaninchen, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt

  • 41
  • 4
  • 1
Kaninchen

Klonalität

  • 43
  • 3
Polyklonal

Konjugat

  • 21
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser IDH3A Antikörper ist unkonjugiert

Applikation

  • 34
  • 13
  • 13
  • 13
  • 12
  • 10
  • 6
  • 3
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 15
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Sequenz

    MKIFDAAKAP IQWEERNVTA IQGPGGKWMI PSEAKESMDK NKMGLKGPLK

    Homologie

    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

    Produktmerkmale

    This is a rabbit polyclonal antibody against IDH3A. It was validated on Western Blot and immunohistochemistry.

    Aufreinigung

    Protein A purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the N terminal region of human IDH3A
  • Applikationshinweise

    Optimal working dilutions should be determined experimentally by the investigator.

    Kommentare

    Antigen size: 366 AA

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Lin, Cheng, Tsai, Tsai, Hu, Chang, Yeh, Chen, Liao, Chang: "Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy." in: Scientific reports, Vol. 2, pp. 785, (2012) (PubMed).

  • Target

    IDH3A (Isocitrate Dehydrogenase 3 (NAD+) alpha (IDH3A))

    Andere Bezeichnung

    IDH3A

    Hintergrund

    Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. IDH3A is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase.Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase.
    Protein Interaction Partner: HUWE1, SUMO2, STAU1, UBC, MDM2, ADRB2, gag-pol, RAB4A, MBNL1, S100A16, SUCLA2, UQCRFS1P1, SUMO4, EBNA-LP, MYC, TERF2, TERF1, PSMD4, DDA1, DMWD, IDH3B, IDH3G,
    Protein Size: 366

    Molekulargewicht

    40 kDa

    Gen-ID

    3419

    NCBI Accession

    NM_005530, NP_005521

    UniProt

    P50213
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