Klotho Antikörper (N-Term)

Produktnummer ABIN2774900

Der Kaninchen Polyklonal anti-Klotho Antikörper (ABIN2774900) detektiert spezifisch Klotho in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Maus, Human, Ratte, Kaninchen, Pferd, Rind (Kuh) und Schwein.

Kurzübersicht für Klotho Antikörper (N-Term) (ABIN2774900)

Target: Klotho (KL)

Reaktivität: Maus, Human, Ratte, Kaninchen, Pferd, Rind (Kuh), Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Klotho Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Klotho Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: Kl Antibody - N-terminal region

Sequenz: GAAPSDSPIV VAPSGAPSPP LSSTGDVASD SYNNVYRDTE GLRELGVTHY

Homologie: Cow: 93%, Horse: 93%, Human: 100%, Mouse: 92%, Pig: 91%, Rabbit: 92%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against Kl. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP36671-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Klotho

Target: Klotho (KL)

Andere Bezeichnung: Kl

Hintergrund:

Background Information: Kl may have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. It may be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1.

Gene Name: Klotho

Alternative Symbols: alp, alpha-kl

Protein Name: Klotho

Molekulargewicht: 116kDa

Gen-ID: 16591

NCBI Accession: NP_038851

UniProt: O35082

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Hormone Activity, Growth Factor Binding