Annexin VII Antikörper (N-Term)

Produktnummer ABIN2774843

Produktdetails anti-Annexin VII Antikörper

Target: Annexin VII (ANXA7) (Annexin A7 (ANXA7))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Annexin VII Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MSYPGYPPTG YPPFPGYPPA GQESSFPPSG QYPYPSGFPP MGGGAYPQVP

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ANXA7. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ANXA7

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 466 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Annexin VII Antikörper (ABIN2774843)

Satoh, Nakano, Shibata, Maki: "The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner." in: Biochimica et biophysica acta, Vol. 1600, Issue 1-2, pp. 61-7, (2002) (PubMed).

Details zu Annexin VII

Target: Annexin VII (ANXA7) (Annexin A7 (ANXA7))

Andere Bezeichnung: ANXA7 (ANXA7 Produkte)

Synonyme: ANX7 antikoerper, SNX antikoerper, SYNEXIN antikoerper, AI265384 antikoerper, AI316497 antikoerper, Anx7 antikoerper, synexin antikoerper, anxa7 antikoerper, MGC76267 antikoerper, MGC82023 antikoerper, ANXA7 antikoerper, MGC83033 antikoerper, annexin A7 antikoerper, annexin VII antikoerper, annexin A7 S homeolog antikoerper, ANXA7 antikoerper, Anxa7 antikoerper, anxa7 antikoerper, anxa7.S antikoerper, PTRG_02166 antikoerper, BRAFLDRAFT_231082 antikoerper, PAAG_00136 antikoerper, MCYG_04180 antikoerper, VDBG_06328 antikoerper, MGYG_02426 antikoerper

Hintergrund: ANXA7 is a member of the annexin family of calcium-dependent phospholipid binding proteins. The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. The selection of poly(A) signals is independent of the mRNA splicing pattern. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion.
Alias Symbols: SNX, ANX7, SYNEXIN
Protein Interaction Partner: UBC, PAX8, ATP4A, SRC, Prkcb, Prkcg, Prkca, PRKG1, PRKACA, VCP, ANXA4, CUL4B, CUL5, ALG2, ELAVL1, CCDC90B, WDR18, LRIF1, OTUB1, CPSF3L, SEMA5B, INPP5K, ACTL6B, CSAD, SDF4, MED31, TAF5L, TRMT2A, TUBB2B, CPNE2, ZNF431, KLHL23, DOCK7, WDR73, FBN3, RBM48, ADA
Protein Size: 466

Molekulargewicht: 51 kDa

Gen-ID: 310

NCBI Accession: NM_001156, NP_001147

UniProt: Q5T0M6