DTX2 Antikörper (C-Term)

Produktnummer ABIN2774772

Produktdetails anti-DTX2 Antikörper

Target: DTX2 (Deltex Homolog 2 (DTX2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Zebrafisch (Danio rerio), Kaninchen, Ziege, Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DTX2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: EDCGTILIVY SIPHGIQGPE HPNPGKPFTA RGFPRQCYLP DNAQGRKVLE

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against DTX2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DTX2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 575 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DTX2

Target: DTX2 (Deltex Homolog 2 (DTX2))

Andere Bezeichnung: DTX2 (DTX2 Produkte)

Synonyme: RNF58 antikoerper, 2610524D08Rik antikoerper, AA408415 antikoerper, AU022494 antikoerper, Deltex2 antikoerper, dtx2 antikoerper, deltex E3 ubiquitin ligase 2 antikoerper, probable E3 ubiquitin-protein ligase DTX2 antikoerper, deltex 2, E3 ubiquitin ligase antikoerper, deltex 2, E3 ubiquitin ligase S homeolog antikoerper, DTX2 antikoerper, Dtx2 antikoerper, LOC735784 antikoerper, LOC747633 antikoerper, dtx2 antikoerper, dtx2.S antikoerper

Hintergrund: DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. DTX2 probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context and mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. It also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Alias Symbols: KIAA1528, MGC71098, RNF58
Protein Interaction Partner: KRTAP26-1, RFX6, KLC3, GLYCTK, DTX2, RIMBP3, C1orf94, NCALD, PLEKHF2, TRIM54, EIF4ENIF1, ALKBH4, UBE2D4, HPCAL4, SPG21, SEC22A, SPAG8, STX12, NCS1, FAM168A, RBPMS, SEC23B, ABHD16A, VSNL1, SUMO1, UBE2D3, UBE2D1, UBC, TRIP6, QARS, HDC, GOLGA2, FHL2, ARNT2,
Protein Size: 575

Molekulargewicht: 62 kDa

Gen-ID: 113878

NCBI Accession: NM_001102596, NP_001096066

UniProt: Q6XM87

Pathways: Notch Signalweg