MARCH5 Antikörper (N-Term)

Produktnummer ABIN2774746

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-MARCH5 Antikörper wird verwendet zum Nachweis von MARCH5 in Proben von Human, Maus, Ratte, Rind (Kuh), Zebrafisch (Danio rerio), Hund, Meerschweinchen, Pferd und Kaninchen. Er wurde validiert für WB.

Kurzübersicht für MARCH5 Antikörper (N-Term) (ABIN2774746)

Target: MARCH5 (Membrane-Associated Ring Finger (C3HC4) 5 (MARCH5))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Zebrafisch (Danio rerio), Hund, Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MARCH5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MARCH5 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: MARCH5 Antibody - N-terminal region

Sequenz: CRGSTKWVHQ ACLQRWVDEK QRGNSTARVA CPQCNAEYLI VFPKLGPVVY

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MARCH5. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MARCH5

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP43232-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-MARCH5 Antikörper (ABIN2774746)

Cilenti, Ambivero, Ward, Alnemri, Germain, Zervos: "Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy." in: Biochimica et biophysica acta, Vol. 1843, Issue 7, pp. 1295-307, (2014) (PubMed).

Details zu MARCH5

Target: MARCH5 (Membrane-Associated Ring Finger (C3HC4) 5 (MARCH5))

Andere Bezeichnung: MARCH5

Hintergrund:

Background Information: MARCH5 is an ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2) and DRP1 (DNM1L). MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2, MIM 608507) and DRP1 (DNM1L, MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1502 AK000452.1 3-1504 1503-1863 BC015480.1 1463-1823 1864-1901 BE393612.1 438-475 1902-3713 BC015480.1 1852-3663 3714-3941 BC015480.1 3669-3896

Gene Name: Membrane-associated ring finger (C3HC4) 5

Alternative Symbols: MITOL, MARCH5, RNF153, MARCH-V

Protein Name: E3 ubiquitin-protein ligase MARCH5

Molekulargewicht: 31kDa

Gen-ID: 54708

NCBI Accession: NP_060294

UniProt: Q9NX47