FBXO5 Antikörper (C-Term)

Produktnummer ABIN2774700

This anti-FBXO5 antibody (ABIN2774700) is a Rabbit Polyclonal antibody detecting FBXO5 in WB. Suitable for Human, Dog, Pig, Rabbit.

Kurzübersicht für FBXO5 Antikörper (C-Term) (ABIN2774700)

Target: FBXO5 (F-Box Protein 5 (FBXO5))

Reaktivität: Human, Hund, Schwein, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXO5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FBXO5 Antikörper

Bindungsspezifität: C-Term

Sequenz: ASVQKSAAQT SLKKDAQTKL SNQGDQKGST YSRHNEFSEV AKTLKKNESL

Homologie: Dog: 85%, Human: 100%, Pig: 79%, Rabbit: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against FBXO5. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human FBXO5

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 447 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-FBXO5 Antikörper (ABIN2774700)

Estrabaud, Le Rouzic, Lopez-Vergès, Morel, Belaïdouni, Benarous, Transy, Berlioz-Torrent, Margottin-Goguet: "Regulated degradation of the HIV-1 Vpu protein through a betaTrCP-independent pathway limits the release of viral particles." in: PLoS pathogens, Vol. 3, Issue 7, pp. e104, (2007) (PubMed).

Details zu FBXO5

Target: FBXO5 (F-Box Protein 5 (FBXO5))

Andere Bezeichnung: FBXO5

Hintergrund: FBXO5 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein belongs to the Fbxs class and is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified.This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: EMI1, FBX5, Fbxo31
Protein Interaction Partner: FBXW11, UBE2S, SKP1, UBC, TPM3, NEDD8, BRCA1, BARD1, ANAPC1, ANAPC11, ANAPC7, ANAPC5, FZR1, ANAPC4, ANAPC2, CDC16, CDC23, CDC27, CDC20, CDK1, MYC, Gm9174, BTRC, PLK1, EVI5,
Protein Size: 447

Molekulargewicht: 50 kDa

Gen-ID: 26271

NCBI Accession: NM_012177, NP_036309

UniProt: Q9UKT4

Pathways: Mitotic G1-G1/S Phases