TPSB2 Antikörper (Middle Region)

Produktnummer ABIN2774583

Dieses Anti-TPSB2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TPSB2 in WB. Geeignet für Human und Ratte.

Kurzübersicht für TPSB2 Antikörper (Middle Region) (ABIN2774583)

Target: TPSB2 (Tryptase beta 2 (TPSB2))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TPSB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TPSB2 Antikörper

Bindungsspezifität: Middle Region

Sequenz: QALQRVGIVG GQEAPRSKWP WQVSLRVHGP YWMHFCGGSL IHPQWVLTAA

Homologie: Human: 100%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against TPSB2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TPSB2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TPSB2

Target: TPSB2 (Tryptase beta 2 (TPSB2))

Andere Bezeichnung: TPSB2

Hintergrund: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
Alias Symbols: TPS2, tryptaseB, tryptaseC
Protein Size: 282

Molekulargewicht: 31 kDa

Gen-ID: 64499

NCBI Accession: NM_003294, NP_003285

UniProt: P20231