SH2D1A Antikörper (Middle Region)

Produktnummer ABIN2774285

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SH2D1A in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Schwein, Pferd, Kaninchen, Hund und Zebrafisch (Danio rerio).

Kurzübersicht für SH2D1A Antikörper (Middle Region) (ABIN2774285)

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Pferd, Kaninchen, Hund, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SH2D1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SH2D1A Antikörper

Bindungsspezifität: Middle Region

Sequenz: YTYRVSQTET GSWSAETAPG VHKRYFRKIK NLISAFQKPD QGIVIPLQYP

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 90%

Produktmerkmale: This is a rabbit polyclonal antibody against SH2D1A. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human SH2D1A

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SH2D1A

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Andere Bezeichnung: SH2D1A

Hintergrund: SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma.
Protein Interaction Partner: LHX4, TNK2, UBC, LYN, MAPK11, MAPK1, ERBB3, EGFR, MAPK14, CD244, ELAVL1, SLAMF7, SLAMF6, ARHGEF7, CD84, SLAMF1, DOK1, FYB, LY9, ARHGEF6, LCK, FYN, GRB2,
Protein Size: 125

Molekulargewicht: 13 kDa

Gen-ID: 4068

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process