CHN2 Antikörper (N-Term)

Produktnummer ABIN2773996

Der Kaninchen Polyklonal anti-CHN2 Antikörper wird verwendet zum Nachweis von CHN2 in Proben von Human, Maus, Ratte, Rind (Kuh), Pferd, Kaninchen, Hund und Meerschweinchen. Er wurde validiert für WB.

Kurzübersicht für CHN2 Antikörper (N-Term) (ABIN2773996)

Target: CHN2 (Chimerin (Chimaerin) 2 (CHN2))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Pferd, Kaninchen, Hund, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CHN2 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: CHN2 Antibody - N-terminal region

Sequenz: AFGVKVGVKG GFLWPPLKLF ACSQISSLVR RAALTHNDNH FNYEKTHNFK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CHN2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CHN2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8096889

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu CHN2

Target: CHN2 (Chimerin (Chimaerin) 2 (CHN2))

Andere Bezeichnung: CHN2

Hintergrund:

Background Information: CHN2 is a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. CHN2 plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men.This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene Name: Chimerin (chimaerin) 2

Alternative Symbols: BCH, CHN2-3, ARHGAP3, RHOGAP3

Protein Name: Beta-chimaerin

Molekulargewicht: 38kDa

Gen-ID: 1124

NCBI Accession: NP_001035025

UniProt: P52757