MRVI1 Antikörper (N-Term)

Produktnummer ABIN2773963

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MRVI1 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Rind (Kuh), Hund, Meerschweinchen, Pferd, Maus, Kaninchen und Ratte.

Kurzübersicht für MRVI1 Antikörper (N-Term) (ABIN2773963)

Target: MRVI1 (Murine Retrovirus Integration Site 1 Homolog (MRVI1))

Reaktivität: Human, Rind (Kuh), Hund, Meerschweinchen, Pferd, Maus, Kaninchen, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MRVI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MRVI1 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: MRVI1 Antibody - N-terminal region

Sequenz: LVNDQLPDIS ISEEDKKKNL ALLEEAKLVS ERFLTRRGRK SRSSPGDSPS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MRVI1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human MRVI1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP50282-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu MRVI1

Target: MRVI1 (Murine Retrovirus Integration Site 1 Homolog (MRVI1))

Andere Bezeichnung: MRVI1

Hintergrund:

Background Information: This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.

Gene Name: murine retrovirus integration site 1 homolog

Alternative Symbols: IRAG, JAW1L, MRVI1

Protein Name: Protein MRVI1

Molekulargewicht: 88kDa

Gen-ID: 10335

UniProt: Q9Y6F6