SEPN1 Antikörper (C-Term)

Produktnummer ABIN2773903

Produktdetails anti-SEPN1 Antikörper

Target: SEPN1 (Selenoprotein N, 1 (SEPN1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Rind (Kuh), Meerschweinchen, Pferd, Ratte, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SEPN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: ANYFLDITSV KPEEIESNLF SFSSTFEDPS TATYMQFLKE GLRRGLPLLQ

Homologie: Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rat: 100%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against SEPN1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SEPN1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 590 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SEPN1

Target: SEPN1 (Selenoprotein N, 1 (SEPN1))

Andere Bezeichnung: SEPN1 (SEPN1 Produkte)

Synonyme: CFTD antikoerper, MDRS1 antikoerper, RSMD1 antikoerper, RSS antikoerper, SELN antikoerper, 1110019I12Rik antikoerper, AI414492 antikoerper, SePN antikoerper, cb686 antikoerper, wu:fb06g01 antikoerper, wu:fb73d02 antikoerper, wu:fv41b08 antikoerper, zgc:101091 antikoerper, selenoprotein N antikoerper, SELENON antikoerper, Selenon antikoerper, selenon antikoerper

Hintergrund: SEPN1 is a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. Mutations in SEPN1 gene cause the classical phenotype of multiminicore disease and congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Mutations in this gene cause the classical phenotype of multiminicore disease and congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alias Symbols: FLJ24021, MDRS1, RSMD1, RSS, SELN, CFTD
Protein Interaction Partner: ELAVL1, UBC,
Protein Size: 590

Molekulargewicht: 62 kDa

Gen-ID: 57190

NCBI Accession: NM_020451, NP_065184

UniProt: Q9NZV5

Pathways: Skeletal Muscle Fiber Development