SEC63 Antikörper (C-Term)

Produktnummer ABIN2773888

Der Kaninchen Polyklonal anti-SEC63 Antikörper (ABIN2773888) detektiert spezifisch SEC63 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Hund, Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio), Rind (Kuh) und Pferd.

Kurzübersicht für SEC63 Antikörper (C-Term) (ABIN2773888)

Target: SEC63 (SEC63 Homolog (SEC63))

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio), Rind (Kuh), Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SEC63 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SEC63 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: SEC63 Antibody - C-terminal region

Sequenz: WWLYIADRKE QTLISMPYHV CTLKDTEEVE LKFPAPGKPG NYQYTVFLRS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against SEC63. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SEC63

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8111229

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu SEC63

Target: SEC63 (SEC63 Homolog (SEC63))

Andere Bezeichnung: SEC63

Hintergrund:

Background Information: The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. SEC63 and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. SEC63 is an integral membrane protein located in the rough ER.The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.

Gene Name: SEC63 homolog (S. cerevisiae)

Alternative Symbols: ERdj2, PCLD2, SEC63L, DNAJC23, PRO2507

Protein Name: Translocation protein SEC63 homolog

Molekulargewicht: 88kDa

Gen-ID: 11231

NCBI Accession: NP_009145

UniProt: Q9UGP8

Pathways: ER-Nucleus Signaling