FHIT Antikörper (AA 2-150) (FITC)

Produktnummer ABIN2754854

Dieses Anti-FHIT-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FHIT in ELISA. Geeignet für Maus.

Kurzübersicht für FHIT Antikörper (AA 2-150) (FITC) (ABIN2754854)

Target: FHIT (Fragile Histidine Triad (FHIT))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FHIT Antikörper ist konjugiert mit FITC

Applikation: ELISA

Produktdetails anti-FHIT Antikörper (FITC)

Bindungsspezifität: AA 2-150

Kreuzreaktivität: Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Mouse Bis(5\\\'-adenosyl)-triphosphatase protein (2-150AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu FHIT

Target: FHIT (Fragile Histidine Triad (FHIT))

Andere Bezeichnung: Fhit

Hintergrund:

Background: Cleaves P(1)-P(3)-bis(5\\\'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5\\\'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5\\\'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity (By similarity). Functions as tumor suppressor.

Aliases: FhitBis(5'-adenosyl)-triphosphatase antibody, EC 3.6.1.29 antibody, AP3A hydrolase antibody, AP3Aase antibody, Diadenosine 5',5'''-P1,P3-triphosphate hydrolase antibody, Dinucleosidetriphosphatase antibody, Fragile histidine triad protein antibody

UniProt: O89106