CD68 Antikörper (PE)

Produktnummer ABIN2749210

Produktdetails anti-CD68 Antikörper (PE)

Target: CD68 (CD68 Molecule (CD68))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD68 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Verwendungszweck: Anti-Hu CD68 PE

Spezifität: The mouse monoclonal antibody Y1/82A recognizes CD68 (LAMP4), a 110 kDa glycoprotein expressed mainly in cytoplasmic granules of monocytes/macrophages, granulocytes, and dendritic cells.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: Lysosomal contents of lung macrophages

Klon: Y1-82A

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. Extracellular and intracellular staining.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Referenzen für anti-CD68 Antikörper (PE) (ABIN2749210)

Yamagami, Yokoo, Amano, Ebihara: "Characterization of bone marrow derived cells in the substantia propria of the human conjunctiva." in: Investigative ophthalmology & visual science, Vol. 48, Issue 10, pp. 4476-81, (2007) (PubMed).

Mack, Tucker, Sokol, Karrer, Kotzin, Whitington, Miller: "Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation." in: Pediatric research, Vol. 56, Issue 1, pp. 79-87, (2004) (PubMed).

Ulanova, Tarkowski, Hahn-Zoric, Hanson: "The Common vaccine adjuvant aluminum hydroxide up-regulates accessory properties of human monocytes via an interleukin-4-dependent mechanism." in: Infection and immunity, Vol. 69, Issue 2, pp. 1151-9, (2001) (PubMed).

Doussis, Gatter, Mason: "CD68 reactivity of non-macrophage derived tumours in cytological specimens." in: Journal of clinical pathology, Vol. 46, Issue 4, pp. 334-6, (1993) (PubMed).

Holness, Simmons: "Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins." in: Blood, Vol. 81, Issue 6, pp. 1607-13, (1993) (PubMed).

Details zu CD68

Target: CD68 (CD68 Molecule (CD68))

Andere Bezeichnung: CD68 (CD68 Produkte)

Hintergrund: CD68 Molecule,CD68 (also known as LAMP4 or SCARD1) is a 110 kDa type I transmembrane glycoprotein of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family and the scavenger receptor family. Although CD68 primarily localizes to lysosomes and endosomes, its fraction circulates to the cell surface. By the heavily glycosylated extracellular domain CD68 binds to tissue- and organ-specific lectins or selectins. It is expressed mainly in cytoplasmic granules of monocytes/macrophages, granulocytes, and dendritic cells, but also e.g. in a proportion of epithelial tumours (diagnosis of poorly differentiated neoplasms).,GP110, LAMP4, SCARD1

Gen-ID: 968

UniProt: P34810