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CD8 alpha Antikörper

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch CD8 alpha in FACS, IP, IHC (fro), IHC (p) und ICC. Er zeigt eine Reaktivität gegenüber Maus und wurde in 8+ Publikationen erwähnt.
Produktnummer ABIN2749187

Kurzübersicht für CD8 alpha Antikörper (ABIN2749187)

Target

Alle CD8 alpha (CD8A) Antikörper anzeigen
CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Reaktivität

  • 291
  • 129
  • 58
  • 46
  • 13
  • 11
  • 7
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Maus

Wirt

  • 241
  • 163
  • 105
  • 3
  • 2
Ratte

Klonalität

  • 383
  • 125
  • 3
Monoklonal

Konjugat

  • 180
  • 50
  • 33
  • 32
  • 31
  • 9
  • 9
  • 8
  • 8
  • 8
  • 8
  • 8
  • 7
  • 7
  • 7
  • 6
  • 6
  • 6
  • 6
  • 5
  • 5
  • 5
  • 5
  • 4
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CD8 alpha Antikörper ist unkonjugiert

Applikation

  • 360
  • 176
  • 126
  • 101
  • 73
  • 71
  • 39
  • 35
  • 22
  • 22
  • 20
  • 15
  • 14
  • 11
  • 9
  • 7
  • 7
  • 6
  • 6
  • 5
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Klon

53-6-7
  • Verwendungszweck

    Anti-Ms CD8a Purified

    Spezifität

    The rat monoclonal antibody 53-6.7 recognizes an extracellular epitope of murine CD8a (32-34 kDa, alpha chain of the CD8 antigen).

    Kreuzreaktivität (Details)

    Mouse

    Aufreinigung

    Purified by protein-G affinity chromatography.

    Reinheit

    > 95 % (by SDS-PAGE)

    Immunogen

    Murine spleen cells

    Isotyp

    IgG2a kappa
  • Applikationshinweise

    Flow cytometry: Recommended dilution: 1.5 μg/mL.
    Immunohistochemistry (frozen sections): Recommended dilution: 1:1000, formaldehyde fixation is not recommended, acetone fixation is preferred.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1 mg/mL

    Buffer

    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Do not freeze.
  • Mochimaru, Usui, Yaguchi, Nagahama, Hasegawa, Usui, Shimmura, Tsubota, Amano, Kawakami, Ishida: "Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2." in: Investigative ophthalmology & visual science, Vol. 49, Issue 5, pp. 2172-7, (2008) (PubMed).

    Bouwer, Alberti-Segui, Montfort, Berkowitz, Higgins: "Directed antigen delivery as a vaccine strategy for an intracellular bacterial pathogen." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 13, pp. 5102-7, (2006) (PubMed).

    Kamimura, Sawa, Sato, Agung, Hirano, Murakami: "IL-2 in vivo activities and antitumor efficacy enhanced by an anti-IL-2 mAb." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 1, pp. 306-14, (2006) (PubMed).

    Hata, Sakaguchi, Yoshitomi, Iwakura, Sekikawa, Azuma, Kanai, Moriizumi, Nomura, Nakamura, Sakaguchi: "Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice." in: The Journal of clinical investigation, Vol. 114, Issue 4, pp. 582-8, (2004) (PubMed).

    Grabbe, Varga, Beissert, Steinert, Pendl, Seeliger, Bloch, Peters, Schwarz, Sunderkötter, Scharffetter-Kochanek: "Beta2 integrins are required for skin homing of primed T cells but not for priming naive T cells." in: The Journal of clinical investigation, Vol. 109, Issue 2, pp. 183-92, (2002) (PubMed).

    Takahashi, Nakata, Tanaka, Adachi, Nakauchi, Yagita, Okumura: "CD4 and CD8 regulate interleukin 2 responses of T cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 12, pp. 5557-61, (1992) (PubMed).

    Ledbetter, Herzenberg: "Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens." in: Immunological reviews, Vol. 47, pp. 63-90, (1980) (PubMed).

    Ledbetter, Rouse, Micklem, Herzenberg: "T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views." in: The Journal of experimental medicine, Vol. 152, Issue 2, pp. 280-95, (1980) (PubMed).

  • Target

    CD8 alpha (CD8A) (CD8a Molecule (CD8A))

    Andere Bezeichnung

    CD8a

    Hintergrund

    CD8a molecule,The CD8a (CD8 alpha) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.,Ly-2, Ly-B, Ly-35, Lyt-2, BB154331

    Gen-ID

    12525

    UniProt

    P01731

    Pathways

    T-Zell Rezeptor Signalweg
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