CD8 alpha Antikörper
CD8A
Reaktivität: Maus
FACS, IP, IHC (fro), IHC (p), ICC
Wirt: Ratte
Monoclonal
53-6-7
unconjugated
(8 Referenzen)-
- Target Alle CD8 alpha (CD8A) Antikörper anzeigen
- CD8 alpha (CD8A) (CD8a Molecule (CD8A))
- Reaktivität
- Maus
- Wirt
- Ratte
- Klonalität
- Monoklonal
- Applikation
- Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
- Verwendungszweck
- Anti-Ms CD8a Purified
- Spezifität
- The rat monoclonal antibody 53-6.7 recognizes an extracellular epitope of murine CD8a (32-34 kDa, alpha chain of the CD8 antigen).
- Kreuzreaktivität (Details)
- Mouse
- Aufreinigung
- Purified by protein-G affinity chromatography.
- Reinheit
- > 95 % (by SDS-PAGE)
- Immunogen
- Murine spleen cells
- Klon
- 53-6-7
- Isotyp
- IgG2a kappa
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- Applikationshinweise
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Flow cytometry: Recommended dilution: 1.5 μg/mL.
Immunohistochemistry (frozen sections): Recommended dilution: 1:1000, formaldehyde fixation is not recommended, acetone fixation is preferred. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store at 2-8°C. Do not freeze.
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: "Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2." in: Investigative ophthalmology & visual science, Vol. 49, Issue 5, pp. 2172-7, (2008) (PubMed).
: "Directed antigen delivery as a vaccine strategy for an intracellular bacterial pathogen." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 13, pp. 5102-7, (2006) (PubMed).
: "IL-2 in vivo activities and antitumor efficacy enhanced by an anti-IL-2 mAb." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 1, pp. 306-14, (2006) (PubMed).
: "Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice." in: The Journal of clinical investigation, Vol. 114, Issue 4, pp. 582-8, (2004) (PubMed).
: "Beta2 integrins are required for skin homing of primed T cells but not for priming naive T cells." in: The Journal of clinical investigation, Vol. 109, Issue 2, pp. 183-92, (2002) (PubMed).
: "CD4 and CD8 regulate interleukin 2 responses of T cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 12, pp. 5557-61, (1992) (PubMed).
: "Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens." in: Immunological reviews, Vol. 47, pp. 63-90, (1980) (PubMed).
: "T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views." in: The Journal of experimental medicine, Vol. 152, Issue 2, pp. 280-95, (1980) (PubMed).
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: "Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2." in: Investigative ophthalmology & visual science, Vol. 49, Issue 5, pp. 2172-7, (2008) (PubMed).
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- Target
- CD8 alpha (CD8A) (CD8a Molecule (CD8A))
- Andere Bezeichnung
- CD8a
- Hintergrund
- CD8a molecule,The CD8a (CD8 alpha) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.,Ly-2, Ly-B, Ly-35, Lyt-2, BB154331
- Gen-ID
- 12525
- UniProt
- P01731
- Pathways
- T-Zell Rezeptor Signalweg
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