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ICAM-3/CD50 Antikörper

ICAM3 Reaktivität: Human FACS, IHC (p), Func Wirt: Maus Monoclonal MEM-04 unconjugated
Produktnummer ABIN2749029
  • Target Alle ICAM-3/CD50 (ICAM3) Antikörper anzeigen
    ICAM-3/CD50 (ICAM3) (Intercellular Adhesion Molecule 3 (ICAM3))
    Reaktivität
    • 113
    • 3
    • 2
    • 2
    Human
    Wirt
    • 68
    • 44
    • 1
    Maus
    Klonalität
    • 73
    • 40
    Monoklonal
    Konjugat
    • 61
    • 10
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ICAM-3/CD50 Antikörper ist unkonjugiert
    Applikation
    • 62
    • 50
    • 47
    • 34
    • 26
    • 24
    • 23
    • 13
    • 7
    • 7
    • 6
    • 6
    • 6
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Functional Studies (Func)
    Spezifität
    The antibody MEM-04 reacts with an extracellular epitope of CD50 (ICAM-3), a 120-130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells, it is negative on platelets and erythrocytes. The MEM-04 blocks DC-SIGN (CD209) binding to ICAM-3 (epitope in D1).
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified by protein-A affinity chromatography.
    Reinheit
    > 95 % (by SDS-PAGE)
    Endotoxin-Niveau
    Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
    Immunogen
    Leukocytes of a patient suffering from LGL-type leukemia.
    Klon
    MEM-04
    Isotyp
    IgG2b kappa
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  • Applikationshinweise
    Functional application: The antibody MEM-04 blocks DC-SIGN (CD209) binding to ICAM-3 (epitope in D1).
    Flow cytometry: Recommended dilution: 1-4 μg/mL.
    Immunohistochemistry (paraffin sections): Recommended dilution: 10 μg/mL, positive tissue: tonsil.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4
    Konservierungsmittel
    Azide free
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze.
  • Target
    ICAM-3/CD50 (ICAM3) (Intercellular Adhesion Molecule 3 (ICAM3))
    Andere Bezeichnung
    CD50 (ICAM3 Produkte)
    Synonyme
    CD50 antikoerper, CDW50 antikoerper, ICAM-R antikoerper, ICAM-3 antikoerper, ICAM3 antikoerper, intercellular adhesion molecule 3 antikoerper, ICAM3 antikoerper, Icam3 antikoerper
    Hintergrund
    Intercellular adhesion molecule 3,CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages, this process is involved in dialogue between dendritic cells and granulocytes.,ICAM-3, ICAM-R
    Gen-ID
    3385
    UniProt
    P32942
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