GGCX Antikörper (AA 150-200)

Produktnummer ABIN2747828

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GGCX in ELISA, WB, IHC und IP. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für GGCX Antikörper (AA 150-200) (ABIN2747828)

Target: GGCX (gamma-Glutamyl Carboxylase (GGCX))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GGCX Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Produktdetails anti-GGCX Antikörper

Bindungsspezifität: AA 150-200

Spezifität: The antibody labels a strong band of GGCX at 91 kDa in ABIN1741677 samples and in other cancer cell lines.

Kreuzreaktivität: Maus

Kreuzreaktivität (Details): The antibody does not cross react to any other cellular protein.

Produktmerkmale: Vitamin K dependent GGCX selective antibodies were generated against a peptide taken from the human protein. The GGCX-selective antibodies are affinity purified on an immobilized antigen based affinity matrix, the isolated antibodies were then stabilized in antibody stabilization buffer for long-term storage. The GGCX-selective antibodies are fully characterized for applications in western blotting and ELISA at the recommended dilutions. The supplier Provides GGCX Western blot positive control samples in ready-to-use SDS-PAGE sample buffer. Limited quantities of antigenic blocking peptide for GGCX antibody is also available, please inquire before ordering.FabGennix Intl. Inc. provides custom antibody production services for researchers that are looking for high affinity mono and polyclonal antibodies in various host animal species. We specialize in making application specific antibodies that are useful in IHC, confocal and other applications where native antigen is detected.

Aufreinigung: Affinity Purified

Immunogen: Synthetic peptide taken within amino acid region 150-200 on human GGCX protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Synonyms: Vitamin K-dependent gamma-carboxylase, GGCX, GC, VKCFD1

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.55-0.75 μg/μL

Handhabung: Working solutions of antibodies in buffer should be filtered through 0.45 μm filter after every use for long-term storage.

Lagerung: -20 °C

Informationen zur Lagerung: For long-term storage of keep at -20 °C. We don't recommend storage of very dilute antibody solutions unless they are prepared in specially formulated multi use antibody dilution buffer.

Details zu GGCX

Target: GGCX (gamma-Glutamyl Carboxylase (GGCX))

Andere Bezeichnung: GGCX

Hintergrund: GGCX is a multi-pass membrane protein, localized to the membrane of the endoplasmic reticulum. It exists as a monomer and, via its ability to modify glutamate residues, it accomplishes the post-translational changes that are necessary for the activity of all vitamin K-dependent proteins (such as blood coagulation and bone matrix proteins). Vitamin K-dependent Gamma-Carboxylase (GGCX) is an enzyme which catalyzes the posttranslational modification of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) in its substrates, the vitamin K-dependent proteins (VKDPs). This modification is required for the functional activity of coagulation proteins such as factors VII, IX, X, and prothrombin. The VKDPs play an important role as signaling molecules in the regulation of cell growth, adhesion, and apoptosis. The modification is carried out by a system of integral proteins of the endoplasmic reticulum (ER) membrane where the warfarin sensitive vitamin K 2, 3-epoxide reductase (VKOR) produces the reduced hydroquinone form of vitamin K (vit.KH2) needed by the gamma-carboxylase as the active cofactor. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent clotting factor 1 (VKCFD1) defect and Pseudoxanthoma Elasticum, PXE-like disorder with multiple coagulation factor deficiency, both of which are characterized by abnormal skin, blood or bone function. This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complex with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudo gene of this locus is located at an adjacent region on chromosome 3. The modification has a wide range of physiological implications, including hemostasis, bone calcification, and signal transduction. This enzyme interacts with a high affinity gamma-carboxylation recognition sequence (gamma-CRS) of the substrate and carries out multiple modifications of the substrate before the product is released. The human GGCX gene maps to chromosome 2 at 2p12 and encodes a 758 amino acid protein.

UniProt: P38435

Pathways: SARS-CoV-2 Protein Interaktom