PDE4D PKA Site (AA 50-100), (N-Term), (phosphorylated) Antikörper

Produktnummer ABIN2747156

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PDE4D PKA Site in ELISA, IHC (p), IP und WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte. Es wurde in 4+ Publikationen zitiert.

Kurzübersicht für PDE4D PKA Site (AA 50-100), (N-Term), (phosphorylated) Antikörper (ABIN2747156)

Target: PDE4D PKA Site

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)

Produktdetails

Bindungsspezifität: AA 50-100, N-Term, phosphorylated

Aufreinigung: Affinity Purified

Immunogen: Phosphorylated synthetic peptide selective for PDE4D PKA site taken within amino acid region 50-100 on human PDE4D8 protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.57 μg/μL

Referenzen

Fu, Kim, Soto, De Arcangelis, DiPilato, Liu, Xu, Shi, Zhang, Xiang: "A long lasting β1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes." in: The Journal of biological chemistry, Vol. 289, Issue 21, pp. 14771-81, (2014) (PubMed).

Mahavadi, Nalli, Kumar, Hu, Kuemmerle, Grider, Murthy: "Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle." in: American journal of physiology. Cell physiology, Vol. 307, Issue 4, pp. C402-11, (2014) (PubMed).

Murthy, Sriwai: "Stimulatory phosphorylation of cAMP-specific PDE4D5 by contractile agonists is mediated by PKC-dependent inactivation of protein phosphatase 2A." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 294, Issue 1, pp. G327-35, (2008) (PubMed).

Zhu, Kelly, Vemavarapu, Thompson, Strada: "Activation and induction of cyclic AMP phosphodiesterase (PDE4) in rat pulmonary microvascular endothelial cells." in: Biochemical pharmacology, Vol. 68, Issue 3, pp. 479-91, (2004) (PubMed).

Antigendetails

Target: PDE4D PKA Site

UniProt: Q08499