PDE1C Antikörper (N-Term)

Produktnummer ABIN2747083

Produktdetails anti-PDE1C Antikörper

Target: PDE1C (phosphodiesterase 1C, Calmodulin-Dependent 70kDa (PDE1C))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE1C Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Confocal Microscopy (CM)

Aufreinigung: Affinity Purified

Immunogen: Synthetic peptide corresponding to unique amino acid sequence on PDE1C gene.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.75-1.25 μg/μL

Referenzen für anti-PDE1C Antikörper (ABIN2747083)

Cesarini, Martini, Vitiani, Gravina, Di Agostino, Graziani, DAlessandris, Pallini, Larocca, Rossi, Jannini, Dolci: "Type 5 phosphodiesterase regulates glioblastoma multiforme aggressiveness and clinical outcome." in: Oncotarget, Vol. 8, Issue 8, pp. 13223-13239, (2017) (PubMed).

Petersen, Kristensen, Jeppesen, Grøndahl, Wissing, Macklon, Andersen: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." in: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).

Yougbaré, Keravis, Abusnina, Decossas, Schall, Muller, Lugnier: "Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling." in: Biochimica et biophysica acta, Vol. 1842, Issue 7, pp. 916-26, (2014) (PubMed).

Abusnina, Keravis, Yougbaré, Bronner, Lugnier: "Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1." in: Molecular nutrition & food research, Vol. 55, Issue 11, pp. 1677-89, (2012) (PubMed).

Abusnina, Alhosin, Keravis, Muller, Fuhrmann, Bronner, Lugnier: "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." in: Cellular signalling, Vol. 23, Issue 1, pp. 152-60, (2011) (PubMed).

Genders, Bradley, Rattigan, Richards: "cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle." in: American journal of physiology. Endocrinology and metabolism, Vol. 301, Issue 2, pp. E342-50, (2011) (PubMed).

Dong, Zitt, Auriga, Hatzelmann, Epstein: "Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells." in: Biochemical pharmacology, Vol. 79, Issue 3, pp. 321-9, (2009) (PubMed).

Deplano, Giorgi, Maccarone, Santone, Nuccetelli, Basso, Bisti: "Gene expression and protein localization of calmodulin-dependent phosphodiesterase during ontogenesis of chick retina." in: Journal of neuroscience research, Vol. 86, Issue 5, pp. 1017-23, (2008) (PubMed).

Murray, Patel, Suda, Zhang, Thistlethwaite, Yuan, Insel: "Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 292, Issue 1, pp. L294-303, (2007) (PubMed).

Dunkern, Hatzelmann: "Characterization of inhibitors of phosphodiesterase 1C on a human cellular system." in: The FEBS journal, Vol. 274, Issue 18, pp. 4812-24, (2007) (PubMed).

Baxendale, Fraser: "Mammalian sperm phosphodiesterases and their involvement in receptor-mediated cell signaling important for capacitation." in: Molecular reproduction and development, Vol. 71, Issue 4, pp. 495-508, (2006) (PubMed).

Dolci, Belmonte, Santone, Giorgi, Pellegrini, Carosa, Piccione, Lenzi, Jannini: "Subcellular localization and regulation of type-1C and type-5 phosphodiesterases." in: Biochemical and biophysical research communications, Vol. 341, Issue 3, pp. 837-46, (2006) (PubMed).

Santone, Giorgi, Maccarone, Basso, Deplano, Bisti: "Gene expression and protein localization of calmodulin-dependent phosphodiesterase in adult rat retina." in: Journal of neuroscience research, Vol. 84, Issue 5, pp. 1020-6, (2006) (PubMed).

Details zu PDE1C

Target: PDE1C (phosphodiesterase 1C, Calmodulin-Dependent 70kDa (PDE1C))

Andere Bezeichnung: PDE1C (PDE1C Produkte)

Synonyme: CG14940 antikoerper, CG14942 antikoerper, CG14943 antikoerper, CG14944 antikoerper, CG31757 antikoerper, CG31758 antikoerper, CG42325 antikoerper, CG44007 antikoerper, Dmel\\CG44007 antikoerper, Dmel_CG14940 antikoerper, Dmel_CG14943 antikoerper, Dmel_CG14944 antikoerper, Dmel_CG31757 antikoerper, Dmel_CG31758 antikoerper, Dmel_CG42325 antikoerper, PDE1C antikoerper, PDE1c antikoerper, GB13690 antikoerper, Hcam3 antikoerper, Phosphodiesterase 1c antikoerper, phosphodiesterase 1C antikoerper, calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A antikoerper, calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C antikoerper, phosphodiesterase 1C, calmodulin-dependent b antikoerper, Pde1c antikoerper, PDE1C antikoerper, LOC724389 antikoerper, LOC100019026 antikoerper, pde1cb antikoerper

NCBI Accession: XP_004857

UniProt: Q14123

Pathways: EGFR Signaling Pathway, Neurotrophin Signalübertragung, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma