PDE1C Antikörper (N-Term)

Produktnummer ABIN2747083

Dieser Anti-PDE1C Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von PDE1C in ELISA, WB, IHC, IF, IP, ICC und CM. Geeignet für Human, Maus und Ratte. Dieses Primary Antibody wurde in 13+ Publikationen zitiert.

Kurzübersicht für PDE1C Antikörper (N-Term) (ABIN2747083)

Target: PDE1C (phosphodiesterase 1C, Calmodulin-Dependent 70kDa (PDE1C))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE1C Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Confocal Microscopy (CM)

Produktdetails anti-PDE1C Antikörper

Bindungsspezifität: N-Term

Aufreinigung: Affinity Purified

Immunogen: Synthetic peptide corresponding to unique amino acid sequence on PDE1C gene.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.75-1.25 μg/μL

Referenzen für anti-PDE1C Antikörper (ABIN2747083)

Cesarini, Martini, Vitiani, Gravina, Di Agostino, Graziani, DAlessandris, Pallini, Larocca, Rossi, Jannini, Dolci: "Type 5 phosphodiesterase regulates glioblastoma multiforme aggressiveness and clinical outcome." in: Oncotarget, Vol. 8, Issue 8, pp. 13223-13239, (2017) (PubMed).

Petersen, Kristensen, Jeppesen, Grøndahl, Wissing, Macklon, Andersen: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." in: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).

Yougbaré, Keravis, Abusnina, Decossas, Schall, Muller, Lugnier: "Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling." in: Biochimica et biophysica acta, Vol. 1842, Issue 7, pp. 916-26, (2014) (PubMed).

Abusnina, Keravis, Yougbaré, Bronner, Lugnier: "Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1." in: Molecular nutrition & food research, Vol. 55, Issue 11, pp. 1677-89, (2012) (PubMed).

Abusnina, Alhosin, Keravis, Muller, Fuhrmann, Bronner, Lugnier: "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." in: Cellular signalling, Vol. 23, Issue 1, pp. 152-60, (2011) (PubMed).

Genders, Bradley, Rattigan, Richards: "cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle." in: American journal of physiology. Endocrinology and metabolism, Vol. 301, Issue 2, pp. E342-50, (2011) (PubMed).

Dong, Zitt, Auriga, Hatzelmann, Epstein: "Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells." in: Biochemical pharmacology, Vol. 79, Issue 3, pp. 321-9, (2009) (PubMed).

Deplano, Giorgi, Maccarone, Santone, Nuccetelli, Basso, Bisti: "Gene expression and protein localization of calmodulin-dependent phosphodiesterase during ontogenesis of chick retina." in: Journal of neuroscience research, Vol. 86, Issue 5, pp. 1017-23, (2008) (PubMed).

Murray, Patel, Suda, Zhang, Thistlethwaite, Yuan, Insel: "Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 292, Issue 1, pp. L294-303, (2007) (PubMed).

Dunkern, Hatzelmann: "Characterization of inhibitors of phosphodiesterase 1C on a human cellular system." in: The FEBS journal, Vol. 274, Issue 18, pp. 4812-24, (2007) (PubMed).

Baxendale, Fraser: "Mammalian sperm phosphodiesterases and their involvement in receptor-mediated cell signaling important for capacitation." in: Molecular reproduction and development, Vol. 71, Issue 4, pp. 495-508, (2006) (PubMed).

Dolci, Belmonte, Santone, Giorgi, Pellegrini, Carosa, Piccione, Lenzi, Jannini: "Subcellular localization and regulation of type-1C and type-5 phosphodiesterases." in: Biochemical and biophysical research communications, Vol. 341, Issue 3, pp. 837-46, (2006) (PubMed).

Santone, Giorgi, Maccarone, Basso, Deplano, Bisti: "Gene expression and protein localization of calmodulin-dependent phosphodiesterase in adult rat retina." in: Journal of neuroscience research, Vol. 84, Issue 5, pp. 1020-6, (2006) (PubMed).

Details zu PDE1C

Target: PDE1C (phosphodiesterase 1C, Calmodulin-Dependent 70kDa (PDE1C))

Andere Bezeichnung: PDE1C

NCBI Accession: XP_004857

UniProt: Q14123

Pathways: EGFR Signaling Pathway, Neurotrophin Signalübertragung, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma