KIF13A Antikörper (Isoform a)

Produktnummer ABIN2746813

Produktdetails anti-KIF13A Antikörper

Target: KIF13A (Kinesin Family Member 13A (KIF13A))

Bindungsspezifität: AA 1700-1800, Isoform a

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIF13A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (IHC)

Spezifität: The antibody labels a strong band of KIF13A at 217 kDa in ABIN1741689 samples and in several cell lines.

Kreuzreaktivität: Affe

Kreuzreaktivität (Details): Does not cross react to any other cellular protein.

Produktmerkmale: KIF13A-selective antibodies are generated against a peptide taken from the C-terminal region. The KIF13A-selective antibodies are affinity purified on an immobilized antigen based affinity matrix, the isolated antibodies were then stabilized in antibody stabilization buffer for longterm storage. The anti-KIF13A-selective antibodies are fully characterized for applications in western blotting and ELISA at the recommended dilutions. The supplier provides KIF13A Western blot positive control samples in ready-to-use SDS-PAGE sample buffer. Limited quantities of antigenic blocking peptide for KIF13A antibody is also available, please inquire before ordering.The supplier, provides custom antibody production services for researchers that are looking for high affinity mono and polyclonal antibodies in various host animal species. We specialize in making application specific antibodies that are useful in IHC, confocal and other applications where native antigen is detected.

Aufreinigung: Affinity Purified

Immunogen: Synthetic peptide taken within amino acid region 1700-1800 on human KIF13A isoform a protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Synonyms: anti-Kinesin family member 13A antibody, kinesin-like protein RBKIN

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.52 μg/μL

Handhabung: Working solutions of antibodies in buffer should be filtered through 0.45 μm filter after every use for long-term storage.

Lagerung: -20 °C

Informationen zur Lagerung: For long-term storage of keep at -20 °C. We don't recommend storage of very dilute antibody solutions unless they are prepared in specially formulated multi use antibody dilution buffer.

Details zu KIF13A

Target: KIF13A (Kinesin Family Member 13A (KIF13A))

Andere Bezeichnung: KIF13A (KIF13A Produkte)

Synonyme: KIF13A antikoerper, RBKIN antikoerper, bA500C11.2 antikoerper, 4930505I07Rik antikoerper, mKIAA4109 antikoerper, kinesin family member 13A antikoerper, kinesin-like protein KIF13A antikoerper, KIF13A antikoerper, LOC534832 antikoerper, Kif13a antikoerper

Hintergrund: KIF13A- selective antibodies were generated The kinesin superfamily of proteins (also known as KIFs) constitutes a large family of over forty KIF microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, mitotic spindle formation, chromosome segregation, cytokinesis, intracellular transport and membrane trafficking events including endocytosis and transcytosis. Structurally, all kinesins contain a motor domain with microtubule and nucleotide binding sites that utilize ATP to target cargo along microtubule filaments. KIF13A is a subfamily of Kinesins that is expressed essentially in the central nervous system in early developmental stages. It functions in positioning of endosomes and directs mannose-6-phosphate receptor-(M6PR) containing vesicles from the trans-Golgi network to the plasma membrane. KIF13A is an end-directed microtubule-dependent motor protein which associates with β1-adaptin, a subunit of the AP-1 adaptor complex. Overexpression of KIF13A results in mislocalization of the AP-1 (Activator Protein 1) and the M6PR. Functional blockade of KIF13A reduces cell surface expression of the M6PR. Thus, KIF13A transports M6PR-containing vesicles and targets the M6PR from TGN to the plasma membrane via direct interaction with the AP-1 adaptor complex. Studies have identified three Kinesin-3 family members-KIF1A, KIF13A, and KIF13B that interact with dendritic vesicle populations to evaluate motor-vesicle interactions in living cells. Mutations in KIF13A gene are associated with occurrence of schizophrenia.

NCBI Accession: NP_071396

UniProt: Q9H1H9