PARP10 Antikörper (AA 1-907)

Produktnummer ABIN2745553

Dieses Anti-PARP10-Antikörper ist ein Ratte Monoklonal-Antikörper zur Detektion von PARP10 in WB, IP und ICC. Geeignet für Human.

Kurzübersicht für PARP10 Antikörper (AA 1-907) (ABIN2745553)

Target: PARP10 (Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10))

Reaktivität: Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser PARP10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Klon: 5H11

Produktdetails anti-PARP10 Antikörper

Bindungsspezifität: AA 1-907

Spezifität: Recognizes human PARP-10 [ARTD10] with an epitope between aa 256-407, containing the glycine rich (G-rich) region.

Kreuzreaktivität: Human

Immunogen: Recombinant human PARP-10 [ARTD10] (aa 1-907) fused to a GST-tag.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Cell culture supernatant containing RPMI, 10 % FCS and 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: +4°C
Stable for at least 1 year after receipt when stored at +4°C.

Haltbarkeit: 12 months

Details zu PARP10

Target: PARP10 (Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10))

Andere Bezeichnung: PARP-10 [ARTD10]

Hintergrund: PARP-10 is a mono-ADP-ribosyltransferase and was initially identified as an interaction partner of the proto-oncoprotein Myc. PARP-10 possesses ubiquitin-interaction motifs, which are important to inhibit the activation of NF-kappaB and downstream target genes in response to interleukin-1beta and tumor necrosis factor-alpha. PARP-10 mono(ADP-ribosyl)ates (MARylates) NEMO (NF-kappaB essential modulator), which results in reduced NEMO polyubiquitylation and thus decreased NF-kappaB signaling. Overexpression of PARP-10 was shown to lead to apoptosis. PARP-10 knockdown leads to increased cell survival. Additional substrates of PARP-10, such as GSK-3beta were identified and PARP-10-mediated mono(ADP-ribosyl)ation (MARylation) was shown to be involved in regulating multiple processes, including Wnt signaling.

UniProt: Q53GL7