TYMS Antikörper

Produktnummer ABIN2745139

Dieser Maus Monoklonal Antikörper erkennt spezifisch TYMS in IF, WB, FACS, IHC, ELISA, IHC (p) und IP. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TYMS Antikörper (ABIN2745139)

Target: TYMS (Thymidylate Synthetase (TYMS))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TYMS Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Klon: TMS715

Produktdetails anti-TYMS Antikörper

Spezifität: Human TS / Thymidylate Synthase

Aufreinigung: Protein G purified

Immunogen: Recombinant human Thymidylate Synthase.

Type of Immunogen: Recombinant protein

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Approved: ELISA, Flo (0.5 - 1 μg/10 x10⁶), IF (0.5 - 1 μg/mL), IHC, IHC-P (0.5 - 1 μg/mL), IP, WB (0.25 - 0.5 μg/mL)

Usage: This antibody is specific for a protein of 36  kDa, identified as Thymidylate Synthase (TS). Thymidylate synthase converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. Thymidylate synthase is also a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates thymidylate synthase by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of thymidylate synthase protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas. ELISA: Order BSA-free antibody format for coating.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS,  pH 7.4, 0.1 mg/mL BSA, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2°C to 8°C.

Details zu TYMS

Target: TYMS (Thymidylate Synthetase (TYMS))

Andere Bezeichnung: TS / Thymidylate Synthase

Hintergrund: Name/Gene ID: TYMS

Synonyms: TYMS, HST422, Thymidylate synthetase, TMS, TS, Thymidylate synthase, Tsase

Gen-ID: 7298

Pathways: Mitotic G1-G1/S Phases