TIMP3 Antikörper (AA 198-211)

Produktnummer ABIN2744876

Der Kaninchen Polyklonal Anti-TIMP3-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, TIMP3 in Proben von Human, Ratte, Rind (Kuh), Hund, Schwein, Schaf, Affe, Schimpanse und Gibbon zu detektieren.

Kurzübersicht für TIMP3 Antikörper (AA 198-211) (ABIN2744876)

Target: TIMP3 (TIMP Metallopeptidase Inhibitor 3 (TIMP3))

Reaktivität: Human, Ratte, Rind (Kuh), Hund, Schwein, Schaf, Affe, Schimpanse, Gibbon

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TIMP3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-TIMP3 Antikörper

Bindungsspezifität: AA 198-211

Spezifität: Human TIMP3

Aufreinigung: Immunoaffinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP3(198-211aa WAPPDKSIINATDP). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset, Ferret, Sheep, Cat, Bovine, Pig, Dog (100%), Mouse, Bat, Hamster, Opossum, Zebra finch, Chicken, Lizard (93%).

Type of Immunogen: Synthetic peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Approved: ELISA (0.1 - 0.5 μg/mL), WB (0.5 - 1 μg/mL)

Usage: The tissue inhibitors of metalloproteinases(TIMPs) are natural inhibitors of the matrix metalloproteinases, a group of zinc-binding endopeptidases involved in the degradation of the extracellular matrix. The TIMP3 gene is expressed in many tissues, with highest expression in the placenta. TIMP3 encodes a potent angiogenesis inhibitor and is mutated in Sorsby fundus dystrophy, a macular degenerative disease with submacular choroidal neovascularization. TIMP3 gene is mapped to 22q12.1-q13.2. Mutations in TIMP3 cause the autosomal dominant disorder Sorsby's fundus dystrophy(SFD).

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Sterile distilled water

Konzentration: Lot specific

Buffer: Lyophilized from PBS, 2.5 % BSA, 0.025 % sodium azide/thimerosal.

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for 1 month or -20°C for longer. Avoid freeze/thaw cycles.

Details zu TIMP3

Target: TIMP3 (TIMP Metallopeptidase Inhibitor 3 (TIMP3))

Andere Bezeichnung: TIMP3

Hintergrund: Name/Gene ID: TIMP3

Synonyms: TIMP3, HSMRK222, K222TA2, MIG-5 protein, K222, SFD, Metalloproteinase inhibitor 3, Protein MIG-5, TIMP-3

Gen-ID: 7078