PLGF Antikörper (AA 206-221)

Produktnummer ABIN2743614

Dieses Anti-PLGF-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PLGF in WB. Geeignet für Human, Schimpanse und Affe.

Kurzübersicht für PLGF Antikörper (AA 206-221) (ABIN2743614)

Target: PLGF (PGF) (Placenta Growth Factor (PGF))

Reaktivität: Human, Schimpanse, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLGF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PLGF Antikörper

Bindungsspezifität: AA 206-221

Spezifität: Human PGF / PLGF

Aufreinigung: Immunoaffinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human PLGF(206-221aa REKMKPERCGDAVPRR). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Monkey (100%), Cat (88%).

Type of Immunogen: Synthetic peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Approved: WB (0.5 - 1 μg/mL)

Usage: Placental growth factor(PGF, also known as PLGF) codes for an angiogenic factor expressed in placental tissue that is similar to vascular permeability factor/vascular endothelial growth factor(VPF/VEGF). It is a glycosylated dimeric secreted protein able to stimulate endothelial cell growth in vitro. PGF is located on chromosome 14 and has been conserved in evolution. It belongs to the family of vascular endothelial growth factors(VEGFs) and binds to the flt-1 VEGF receptor. PLGF-2, which is a PLGF isoform, binds neuropilin-1 and 2 in a heparin-dependent manner. PGF regulates inter- and intra molecular cross talk between the VEGF RTKs Flt1 and Flk1 and stimulates the phosphorylation of specific Flt1 tyrosine residues and the expression of distinct downstream target genes. Moreover, it plays an important role in pathological angiogenic events and with exerting its biological activities through binding to VEGFR1.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Sterile distilled water

Konzentration: Lot specific

Buffer: Lyophilized from PBS, 2.5 % BSA, 0.025 % sodium azide/thimerosal.

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for 1 month or -20°C for longer. Avoid freeze/thaw cycles.

Details zu PLGF

Target: PLGF (PGF) (Placenta Growth Factor (PGF))

Andere Bezeichnung: PGF / PLGF

Hintergrund: Name/Gene ID: PGF
Family: PDGF

Synonyms: PGF, D12S1900, PGFL, PlGF-2, Placental growth factor, Placental growth factor-like, PLGF, Placenta growth factor, SHGC-10760

Gen-ID: 5228

Pathways: VEGFR1 Specific Signals