KRT17 Antikörper

Produktnummer ABIN2742462

Dieses Anti-KRT17-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von KRT17 in WB, IHC, IF, ELISA, FACS, IP und IHC (p). Geeignet für Human, Ratte, Rind (Kuh), Schwein und Ziege.

Kurzübersicht für KRT17 Antikörper (ABIN2742462)

Target: KRT17 (Keratin 17 (KRT17))

Reaktivität: Human, Ratte, Rind (Kuh), Schwein, Ziege

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KRT17 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: E3

Produktdetails anti-KRT17 Antikörper

Spezifität: KRT17 / CK17 / Cytokeratin 17

Aufreinigung: Protein G purified

Immunogen: The cytoskeletal fraction of rat colon epithelium.

Type of Immunogen: Cell fraction

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: Approved: ELISA, Flo (0.5 - 1 μg/10 x10⁶), IF (1 - 2 μg/mL), IHC, IHC-P (0.5 - 1 μg/mL), IP, WB (0.5 - 1 μg/mL)

Usage: Cytokeratin 17 (CK17, Keratin 17) is a member of the Cytokeratin subfamily of intermediate filament proteins (IFP's). It is unique in that it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Cytokeratin 17 is expressed in the nail bed, hair follicle, sebaceous glands and other epidermal appendages. Antibody to cytokeratin 17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands such as mammary, sweat and salivary. It is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered as [Character 93]epithelial stem cell[Character 94] marker because cytokeratin 17 antibody marks basal cell differentiation. Cytokeratin 17 can be useful when included in a panel of antibodies against TTF-1, napsin A, CK5&6, p63, and SOX-2 for diagnostic differentiation between lung adenocarcinoma (LADC) and lung squamous cell carcinoma (SCLC), especially for poorly-differentiated lung carcinoma. Cytokeratin 17 is expressed in SCLC much higher than in LADC. In breast carcinomas, approximately 20 % of patients show no expression of ER, PR and Her2, which are defined as triple negative tumor. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including cytokeratin 17 antibody. Also important is that cases of triple negative breast carcinoma with expression of keratin 17 show an aggressive clinical course. The histologic differentiation of ampullary cancer, intestinal vs. pancreatobiliary, is very important for treatment. Usually antibody to cytokeratin 17 and MUC1 immunoreactivity represents pancreatobiliary subtype whereas antibody to MUC2 and CDX2 positivity defines intestinal subtype. ELISA: Order BSA-free format for coating.

Kommentare:

Target Species of Antibody: Rat

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS,  pH 7.4, 0.1 mg/mL BSA, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2°C to 8°C.

Details zu KRT17

Target: KRT17 (Keratin 17 (KRT17))

Andere Bezeichnung: KRT17 / CK17 / Cytokeratin 17

Hintergrund: Name/Gene ID: KRT17
Family: Keratin

Synonyms: KRT17, 39.1, Cytokeratin 17, Cytokeratin-17, K17, Keratin 17 epitope S2, Keratin 17 epitope S4, Keratin 17, PC2, PCHC1, CK-17, Keratin 17 epitope S1, Keratin-17

Gen-ID: 3872