RUNX2 Antikörper (AA 244-258)

Produktnummer ABIN2738787

Der Kaninchen Polyklonal Anti-RUNX2-Antikörper wurde für WB validiert. Er ist geeignet, RUNX2 in Proben von Human, Maus, Ratte, Hund, Meerschweinchen, Pferd, Schwein, Kaninchen, Affe, Hamster, Schimpanse, Gibbon, Orang-Utan und Schaf zu detektieren.

Kurzübersicht für RUNX2 Antikörper (AA 244-258) (ABIN2738787)

Target: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Pferd, Schwein, Kaninchen, Affe, Hamster, Schimpanse, Gibbon, Orang-Utan, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RUNX2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RUNX2 Antikörper

Bindungsspezifität: AA 244-258

Spezifität: Human CBFA1 / RUNX2

Aufreinigung: Immunoaffinity purified

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human RUNX2(244-258aa DRLSDLGRIPHPSMR). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Baboon, Monkey, Marmoset, Mouse, Ferret, Sheep, Hamster, Elephant, Rabbit, Horse, Pig, Guinea pig, Dog (100%), Turkey, Sparrow, Chicken, Platypus, Lizard (93%).

Type of Immunogen: Synthetic peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Approved: WB (0.5 - 1 μg/mL)

Usage: Core binding factor A1(CBFA1/RUNX2) is a runt-like transcription factor essential for osteoblast differentiation. This protein is a member of the RUNX family of transcription factors and has a Runt DNA-binding domain. It is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. D'Souza et al.(1999) indicate a non-redundant role for Cbfa1 in tooth development that may be distinct from that in bone formation. In odontogenesis, Cbfa1 is not involved in the early signaling networks regulating tooth initiation and early morphogenesis but regulates key epithelial-mesenchymal interactions that control advancing morphogenesis and histodifferentiation of the epithelial enamel organ.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Sterile distilled water

Konzentration: Lot specific

Buffer: Lyophilized from PBS, 2.5 % BSA, 0.025 % sodium azide/thimerosal.

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for 1 month or -20°C for longer. Avoid freeze/thaw cycles.

Details zu RUNX2

Target: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Andere Bezeichnung: CBFA1 / RUNX2

Hintergrund: Name/Gene ID: RUNX2

Synonyms: RUNX2, AML3, CCD, CCD1, OSF2, PEBP2A1, PEBP2A2, PEA2-alpha A, PEBP2-alpha A, OSF-2, PEBP2A, PEBP2aA1, CBF-alpha-1, CBFA1, Oncogene AML-3, PEA2aA, PEBP2aA

Gen-ID: 860