PDE10A Antikörper

Produktnummer ABIN2728473

Produktdetails anti-PDE10A Antikörper

Target: PDE10A (phosphodiesterase 10A (PDE10A))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PDE10A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Produktmerkmale: Homo sapiens phosphodiesterase 10A (PDE10A), transcript variant 2

Aufreinigung: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human PDE10A (NP_006652) produced in HEK293T cell.

Klon: 4A10

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB:1:500, FC:1:50

Kommentare:

The concentration of the product may vary between diferrent lots.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5-1.0 mg/mL

Buffer: PBS ( pH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu PDE10A

Target: PDE10A (phosphodiesterase 10A (PDE10A))

Andere Bezeichnung: PDE10A (PDE10A Produkte)

Synonyme: HSPDE10A antikoerper, Pde10a3 antikoerper, phosphodiesterase 10A antikoerper, PDE10A antikoerper, Pde10a antikoerper

Hintergrund: Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3'cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11, PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously,with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility,platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.

Molekulargewicht: 88.4 kDa

Gen-ID: 10846

NCBI Accession: NM_006661

HGNC: 10846

Pathways: cAMP Metabolic Process