CCM2 Antikörper

Produktnummer ABIN2725240

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CCM2 in WB, IF und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CCM2 Antikörper (ABIN2725240)

Target: CCM2 (Cerebral Cavernous Malformation 2 (CCM2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CCM2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Klon: 2F9

Produktdetails anti-CCM2 Antikörper

Produktmerkmale: Homo sapiens cerebral cavernous malformation 2 (CCM2), transcript variant 2

Aufreinigung: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human CCM2(NP_113631) produced in HEK293T cell.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB 1:2000, IHC 1:150, IF 1:100,

Kommentare:

The concentration of the product may vary between diferrent lots.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu CCM2

Target: CCM2 (Cerebral Cavernous Malformation 2 (CCM2))

Andere Bezeichnung: CCM2

Hintergrund: This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 48.7 kDa

Gen-ID: 83605

NCBI Accession: NM_031443

HGNC: 83605

Pathways: Cell-Cell Junction Organization