YWHAB Antikörper

Produktnummer ABIN272264

Produktdetails anti-YWHAB Antikörper

Target: YWHAB (14-3-3 alpha + beta (YWHAB))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser YWHAB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects endogenous levels of 14-3-3 beta protein. (region surrounding Gln69)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate Buffered Saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu YWHAB

Target: YWHAB (14-3-3 alpha + beta (YWHAB))

Andere Bezeichnung: 14-3-3 Protein beta/alpha (YWHAB Produkte)

Synonyme: GW128 antikoerper, HS1 antikoerper, KCIP-1 antikoerper, YWHAA antikoerper, 1300003C17Rik antikoerper, wu:fb22g04 antikoerper, wu:fr86a12 antikoerper, ywhab antikoerper, ywhab2 antikoerper, zgc:64092 antikoerper, 14-3-3beta antikoerper, fb80c08 antikoerper, fk41f08 antikoerper, wu:fb80c08 antikoerper, wu:fd11d01 antikoerper, wu:fk41f08 antikoerper, ywhab1 antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta S homeolog antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta L homeolog antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a antikoerper, YWHAB antikoerper, Ywhab antikoerper, ywhabb antikoerper, ywhab.S antikoerper, ywhab.L antikoerper, ywhaba antikoerper

Hintergrund: 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 β, γ, ε, ζ, η, θ and σ. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins, by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity and facilitation of protein modification, and thus loss of expression contributes to a vast array of pathogenic cellular activities.Synonyms: KCIP-1, Protein 1054, Protein kinase C inhibitor protein 1, YWHAB

Molekulargewicht: approx. 28 kDa

Gen-ID: 7529

NCBI Accession: NP_003395

UniProt: P31946

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Myometrial Relaxation and Contraction, Maintenance of Protein Location