Recent
ELF5
Reaktivität: Human
ELISA
Wirt: Ziege
Polyclonal
unconjugated
Applikationshinweise
ELISA: 1/20000-1/40000. Western Blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus. This family of genes currently includes Ets-1, Ets-2, Erg-1-3, Elk-1, Elf-1, Elf-5, NERF, PU.1, PEA3, ERM, FEV, ER8l, Fli-1, TEL, Spi-B, ESE-1, ESE-3A, Net, ABT1 and ERF. Members of the Ets gene family exhibit varied patterns of tissue expression, and share a highly conserved carboxy terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. This conserved domain is essential for Ets-1 binding to DNA and is likely to be responsible for the DNA-binding activity of all members of the Ets gene family. Elf-5 is a member of the Ets family that may be involved in lung, mammary, prostate and kidney function, and may also play a role in tumorigenesis.Synonyms: E74-like factor 5, ETS-related transcription factor Elf-5, Elf-5, Epithelium-restricted ESE-1-related Ets factor, Epithelium-specific Ets transcription factor 2