CDK5R2 Antikörper

Produktnummer ABIN272221

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CDK5R2 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für CDK5R2 Antikörper (ABIN272221)

Target: CDK5R2 (Cyclin-Dependent Kinase 5, Regulatory Subunit 2 (p39) (CDK5R2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK5R2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CDK5R2 Antikörper

Spezifität: This antibody detects endogenous levels of p39 protein. (region surrounding asn100)

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu CDK5R2

Target: CDK5R2 (Cyclin-Dependent Kinase 5, Regulatory Subunit 2 (p39) (CDK5R2))

Andere Bezeichnung: CDK5R2

Hintergrund: Cyclin dependent kinases, known as Cdks, regulate transitions in the eukaryotic cell cycle. Cdk 5 is required for proper development of the mammalian central nervous system and is predominantly expressed in neurons. Neuronal Cdk5 can be activated by two accessory proteins designated p35nck5a and p39nck5ai, which is also known as p39. The human p39 gene maps to chromosome 2q35 and encodes a 367-amino acid, 39 kDa protein. p35 and p39 both share limited similarity to cyclins and may define a distinct family of cyclin-dependent kinase activating proteins. During embryonic rat brain development, the expression pattern of p39 appears to have an inverse relationship to that of Cdk5 and p35, suggesting that these proteins may have region-specific and developmental stage-specific functions in rat brain. p39 can localize to lamellipodial and fillopodial structures of cells and in growth cones of neurons. In addition, p39 can colocalize with actin, suggesting that p39 plays a role in regulating actin cytoskeletal dynamics in cells. The temporal and spatial expression of p39 in synaptic junctions indicates a possible role of the p39/cdk5 kinase at the synapse.Synonyms: CDK5 activator 2, Cyclin-dependent kinase 5 activator 2, Cyclin-dependent kinase 5 regulatory subunit 2, NCK5AI, P39, P39I

Molekulargewicht: approx. 40 kDa

Gen-ID: 8941

NCBI Accession: NP_003927

UniProt: Q13319