FOXO1/3/4-pan Antikörper

Produktnummer ABIN271928

Der Kaninchen Polyklonal anti-FOXO1/3/4-pan Antikörper wird verwendet zum Nachweis von FOXO1/3/4-pan in Proben von Human, Maus und Ratte. Er wurde validiert für IHC (p).

Kurzübersicht für FOXO1/3/4-pan Antikörper (ABIN271928)

Target: FOXO1/3/4-pan (FOXO1/3/4) (Forkhead Box O1/3/4 (FOXO1/3/4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXO1/3/4-pan Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-FOXO1/3/4-pan Antikörper

Spezifität: This antibody detects endogenous levels of FOXO1/3/4-pan protein. (region surrounding Pro18/26)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 1000approx. 1: 5000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu FOXO1/3/4-pan

Target: FOXO1/3/4-pan (FOXO1/3/4) (Forkhead Box O1/3/4 (FOXO1/3/4))

Andere Bezeichnung: FOXO1/3/4-Pan

Hintergrund: FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors. FOXO1 (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined. FOX3 probably functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of the FOXO3 gene with the MLL gene is associated with secondary acute leukemia. FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.Synonyms: FOXO1A, FOXO3A, FOXO4A, Forkhead Box Protein O1A, Forkhead in Rhabdomyosarcoma

Molekulargewicht: approx. 70 to 82 kDa