THRB Antikörper
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- Target Alle THRB Antikörper anzeigen
- THRB (Thyroid Hormone Receptor, beta (THRB))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser THRB Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- This antibody detects endogenous levels of Thyroid Hormone Receptor beta protein. (region surrounding Leu37)
- Kreuzreaktivität (Details)
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - Aufreinigung
- Affinity Chromatography using epitope-specific immunogen
- Top Product
- Discover our top product THRB Primärantikörper
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- Applikationshinweise
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ELISA: 1/5000-1/10000. Western Blot: 1/500-1/1000. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- THRB (Thyroid Hormone Receptor, beta (THRB))
- Andere Bezeichnung
- THRB / ERBA2 (THRB Produkte)
- Synonyme
- C-ERBA-2 antikoerper, C-ERBA-BETA antikoerper, ERBA2 antikoerper, GRTH antikoerper, NR1A2 antikoerper, PRTH antikoerper, THR1 antikoerper, THRB1 antikoerper, THRB2 antikoerper, Nr1a2 antikoerper, T3R[b] antikoerper, T3Rbeta antikoerper, Thrb1 antikoerper, Thrb2 antikoerper, c-erbAbeta antikoerper, TR-beta antikoerper, TR[b]1 antikoerper, fj24f03 antikoerper, trb antikoerper, wu:fj24f03 antikoerper, CTR BETA 2 antikoerper, TR-BETA antikoerper, LOC734147 antikoerper, thrb antikoerper, THRB antikoerper, C-erba-beta antikoerper, RATT3REC antikoerper, T3rec antikoerper, TRbeta antikoerper, THR antikoerper, TRbeta1 antikoerper, thyroid hormone receptor beta antikoerper, thyroid hormone receptor, beta antikoerper, thyroid hormone receptor, beta S homeolog antikoerper, thyroid hormone receptor, beta L homeolog antikoerper, THRB antikoerper, Thrb antikoerper, thrb antikoerper, thrb.S antikoerper, thrb.L antikoerper
- Hintergrund
- Thyroid hormone nuclear receptors (TRs) are ligand-dependent transcription factors which regulate growth, differentiation and development and represent members of the steroid/retinoic acid superfamily. The two genes encoding TRs identified to date, TRα and TRβ, have been mapped to human chromosomes 17 and 3, respectively. TRs bind to thyroid hormone response elements(TREs) with half-site binding motifs in the orientation of palindromes, direct repeats or inverted palindromes. The affinities of binding are both variable and influenced differentially by 3,5,3'-triiodo-L-thyronine (T3). Transcriptional regulation by TRs is also modulated by heterodimerization with TR nuclear accessory proteins, the most extensively characterized of which are the retinoid X receptors (RXRα, RXRβ and RXRγ). To a certain extent, this activity is regulated by differential phosphorylation of TRs. Thus, not only are the biological activities of TRs regulated by heterodimerization with RXRs, but in addition, the gene regulatory activities of TRs are linked to other hormonal pathways.Synonyms: NR1A2, Nuclear receptor subfamily 1 group A member 2, THR1, Thyroid hormone receptor beta
- Molekulargewicht
- approx. 42, 55 kDa
- Gen-ID
- 7068
- NCBI Accession
- NP_000452
- UniProt
- P10828
- Pathways
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound
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