APP Antikörper

Produktnummer ABIN2716094

Der Maus Monoklonal anti-APP Antikörper (Klon 6F11) (ABIN2716094) detektiert spezifisch APP in WB, IHC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für APP Antikörper (ABIN2716094)

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser APP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Klon: 6F11

Produktdetails anti-APP Antikörper

Produktmerkmale: Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 1

Aufreinigung: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human APP(NP_000475) produced in HEK23T cell.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: WB 1:2000, IHC 1:150, IF 1:100,

Kommentare:

The concentration of the product may vary between diferrent lots.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu APP

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Andere Bezeichnung: APP

Hintergrund: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Molekulargewicht: 85.1 kDa

Gen-ID: 351

NCBI Accession: NM_000484

HGNC: 351

Pathways: Caspase Kaskade in der Apoptose, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour