Der Maus Monoklonal anti-CD20 Antikörper wird verwendet zum Nachweis von CD20 in Proben von Human, Pavian, Rhesusaffen und Cynomolgus. Er wurde validiert für FACS.
The clone 2H7 recognizes the large extracellular loop of human CD20, mapped to the peptide sequence YNCEPANPSEKNSPST. CD20, a 33-36 kDa non-glycosylated type 1 transmembrane protein, is expressed by developing, resting and mature B cells, some follicular dendritic cells, and a small subset of mature T cells. B cell CD20 expression is lost upon differentiation into plasma cells. Functionally, CD20 activation contributes to B cell activation, proliferation, and differentiation