TACSTD2 Antikörper

Produktnummer ABIN2689944

Produktdetails anti-TACSTD2 Antikörper

Target: TACSTD2 (Tumor-Associated Calcium Signal Transducer 2 (TACSTD2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TACSTD2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Marke: BD Pharmingen™

Produktmerkmale: Trop-2/GA733-1 is a cell surface glycoprotein that was originally identified on human trophoblast and choriocarcinoma cell lines and has been shown to be expressed in most human carcinomas. Trop-2 has been cloned and shown to encode a type-1 transmembrane protein with a single transmembrane domain. Furthermore, research has shown Trop-2 to be involved in the transduction of an intracellular calcium signal, although the exact physiological mechanism has yet to be elucidated. Flow cytometric analysis of Trop-2. MCF7 cells (Human breast adenocarcinoma, ATCC HTB-22) were incubated with 0.25 μg of the Purified Mouse Anti-Human Trop-2 antibody (clone 162-46, shaded) or with a mouse IgG1 isotype control (Cat. No. 555746, unshaded) in BD Pharmingen™ Stain Buffer (Cat. No.554656) for 1 hr on ice. Cells were washed twice in Stain Buffer and incubated with 1 μg of a FITC Goat Anti-Mouse Ig secondary antibody (Cat. No.554001) in Stain Buffer for 1 hr on ice. Cells were washed twice and analyzed by flow cytometry.

BD Pharmingen™ Purified Mouse Anti-Human Trop-2 - Purified - Clone 162-46 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human BeWo (choriocarcinoma) Cell Line

Klon: 162

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-TACSTD2 Antikörper (ABIN2689944)

Bobos, Kotoula, Kaloutsi, Karayannopoulou, Papadimitriou, Kostopoulos: "Aberrant CCND1 copies and cyclin D1 mRNA expression do not result in the production of functional cyclin D1 protein in anaplastic large cell lymphoma." in: Histology and histopathology, Vol. 24, Issue 8, pp. 1035-48, (2009) (PubMed).

Ripani, Sacchetti, Corda, Alberti: "Human Trop-2 is a tumor-associated calcium signal transducer." in: International journal of cancer. Journal international du cancer, Vol. 76, Issue 5, pp. 671-6, (1998) (PubMed).

Fornaro, DellArciprete, Stella, Bucci, Nutini, Capri, Alberti: "Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas." in: International journal of cancer. Journal international du cancer, Vol. 62, Issue 5, pp. 610-8, (1995) (PubMed).

Lipinski, Parks, Rouse, Herzenberg: "Human trophoblast cell-surface antigens defined by monoclonal antibodies." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 78, Issue 8, pp. 5147-50, (1982) (PubMed).

Details zu TACSTD2

Target: TACSTD2 (Tumor-Associated Calcium Signal Transducer 2 (TACSTD2))

Andere Bezeichnung: Trop-2 (TACSTD2 Produkte)

Synonyme: EGP-1 antikoerper, EGP1 antikoerper, GA733-1 antikoerper, GA7331 antikoerper, GP50 antikoerper, M1S1 antikoerper, TROP2 antikoerper, C80403 antikoerper, Ly97 antikoerper, Prp1 antikoerper, tumor associated calcium signal transducer 2 antikoerper, tumor-associated calcium signal transducer 2 antikoerper, TACSTD2 antikoerper, Tacstd2 antikoerper

Hintergrund: Synonyms: GA733-1