SDC4 Antikörper

Produktnummer ABIN2689914

Produktdetails anti-SDC4 Antikörper

Target: SDC4 (Syndecan 4 (SDC4))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser SDC4 Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS)

Marke: BD Pharmingen™

Produktmerkmale: The KY/8.2 mAb reacts with mouse syndecan-4, a cell-surface heparan sulfate proteoglycan. Although the ligand(s) for this molecule is unknown, syndecans are known to interact with the heparin-binding domain of growth factors, chemokines, and extracellular matrix components. Accordingly, heparin inhibits the binding of syndecan-4 to the pre-B cell line BC7.12. Syndecan-4 is localized to focal adhesions and binds protein-kinase Cα. Thus, it is involved in cytoskeletal organization and signaling. Syndecan-4 is expressed on stromal cells and B-lymphocyte precursors in bone marrow, in addition to most splenic B cells and a small population of T lymphocytes. It is highly expressed on activated B lymphocytes, but is downregulated in isotype-switched memory B cells. The ectodomain of syndecan-4 is shed from cell surfaces constitutively and in response to specific physiological signals, and the resulting soluble fragments are functional. Immobilized KY/8.2 mAb induced the formation of dendritic processes on syndecan-4-transfected cells and on anti-CD40-activated splenic B cells. Other methods of activating B cells have not produced the same effect. This antibody recognizes an epitope in the N-terminus of syndecan-4, regardless of post-translational modifications.

BD Pharmingen™ Purified Rat Anti-Mouse Syndecan-4 - Purified - Clone KY/8.2 - Isotype Rat IgG2a, κ - Reactivity Ms - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: BCB10 mouse pre-B cell line

Klon: KY-8-2

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-SDC4 Antikörper (ABIN2689914)

Woods, Couchman: "Syndecan-4 and focal adhesion function." in: Current opinion in cell biology, Vol. 13, Issue 5, pp. 578-83, (2001) (PubMed).

Fitzgerald, Wang, Park, Murphy, Bernfield: "Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase." in: The Journal of cell biology, Vol. 148, Issue 4, pp. 811-24, (2000) (PubMed).

Yamashita, Oritani, Miyoshi, Wall, Bernfield, Kincade: "Syndecan-4 is expressed by B lineage lymphocytes and can transmit a signal for formation of dendritic processes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 10, pp. 5940-8, (1999) (PubMed).

Rapraeger, Ott: "Molecular interactions of the syndecan core proteins." in: Current opinion in cell biology, Vol. 10, Issue 5, pp. 620-8, (1998) (PubMed).

Details zu SDC4

Target: SDC4 (Syndecan 4 (SDC4))

Andere Bezeichnung: Syndecan-4 (SDC4 Produkte)

Synonyme: SYND4 antikoerper, AA959608 antikoerper, AW108331 antikoerper, Synd4 antikoerper, ryudocan antikoerper, syndecan-4 antikoerper, RATRYUDOCA antikoerper, RYUDOCA antikoerper, SDC4 antikoerper, sdc4l antikoerper, wu:fc47g09 antikoerper, Syndecan-4 antikoerper, amphiglycan antikoerper, syn-4 antikoerper, syn4 antikoerper, syndecan 4 antikoerper, syndecan 4 S homeolog antikoerper, syndecan 4 L homeolog antikoerper, SDC4 antikoerper, Sdc4 antikoerper, sdc4 antikoerper, sdc4.S antikoerper, sdc4.L antikoerper

Pathways: Glycosaminoglycan Metabolic Process