CD207 Antikörper

Produktnummer ABIN2689803

Der Maus Monoklonal Anti-CD207-Antikörper wurde für IHC und ICS validiert. Er ist geeignet, CD207 in Proben von Human zu detektieren. Es sind 5+ Publikationen verfügbar.

Kurzübersicht für CD207 Antikörper (ABIN2689803)

Target: CD207 (CD207 Molecule, Langerin (CD207))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD207 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Intracellular Staining (ICS)

Klon: 2G3

Produktdetails anti-CD207 Antikörper

Marke: BD Pharmingen™

Produktmerkmale: The 2G3 monoclonal antibody specifically binds to Langerin which is also known as CD207 or C-type lectin domain family 4 member K (CLEC4K). CD207 is a 48 kDa type II transmembrane glycoprotein that belongs to the C-type lectin family. CD207 is selectively expressed by Langerhans cells, an immature dendritic cell type that is found in the epidermis and mucosal epithelia, and by some other dendritic cell subsets. CD207 is expressed on the cell surface membrane and by intracellular Birbeck granules whose formation depends on CD207. CD207 binds to certain surface carbohydrates that are expressed by microbes. It appears to play a role in the uptake of these microbes for subsequent processing and microbial antigen presentation to T cells. Immunohistochemical analysis of Langerin (CD207) expression by Langerhans cells within human skin. Acetone-fixed, frozen huma skin sections were stained with either Purified Mouse IgG1 κ Isotype Control (Cat. No. 550878, Left Image) or Purified Mouse Anti-Human Langerin (CD207) antibody (Cat. No. 564789, Right Image). A three-step staining procedure that employed Biotin Goat Anti-Mouse Ig (Cat. No. 550337), Streptavidin-Horseradish Peroxidase (HRP) (Cat. No. 550946), and the DAB Substrate Kit (Cat. No. 550880) was used to develop the primary staining reagents. Original magnification: 40x.

BD Pharmingen™ Purified Mouse Anti-Human Langerin (CD207) - Purified - Clone 2G3 (also known as AB5_8.2G3.6 ) - Isotype Mouse IgG1, λ - Reactivity Hu - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Langerin Recombinant Protein

Isotyp: IgG1 lambda

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-CD207 Antikörper (ABIN2689803)

Mayumi, Watanabe, Norose, Watari, Kawana, Geijtenbeek, Takahashi: "E-cadherin interactions are required for Langerhans cell differentiation." in: European journal of immunology, Vol. 43, Issue 1, pp. 270-80, (2013) (PubMed).

Flamar, Zurawski, Scholz, Gayet, Ni, Li, Klechevsky, Quinn, Oh, Kaplan, Banchereau, Zurawski: "Noncovalent assembly of anti-dendritic cell antibodies and antigens for evoking immune responses in vitro and in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 5, pp. 2645-55, (2012) (PubMed).

Igyártó, Haley, Ortner, Bobr, Gerami-Nejad, Edelson, Zurawski, Malissen, Zurawski, Berman, Kaplan: "Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses." in: Immunity, Vol. 35, Issue 2, pp. 260-72, (2011) (PubMed).

de Witte, Nabatov, Pion, Fluitsma, de Jong, de Gruijl, Piguet, van Kooyk, Geijtenbeek: "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells." in: Nature medicine, Vol. 13, Issue 3, pp. 367-71, (2007) (PubMed).

Valladeau, Ravel, Dezutter-Dambuyant, Moore, Kleijmeer, Liu, Duvert-Frances, Vincent, Schmitt, Davoust, Caux, Lebecque, Saeland: "Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules." in: Immunity, Vol. 12, Issue 1, pp. 71-81, (2000) (PubMed).

Details zu CD207

Target: CD207 (CD207 Molecule, Langerin (CD207))

Andere Bezeichnung: Langerin CD207

Hintergrund: Synonyms: CLC4K, CLEC4K, C-type lectin domain family 4 member K