Interleukin 17a Antikörper (Biotin)

Produktnummer ABIN2689740

Der Ratte Monoklonal Anti-Interleukin 17a-Antikörper wurde für ELISA und WB validiert. Er ist geeignet, Interleukin 17a in Proben von Maus zu detektieren. Es sind 4+ Publikationen verfügbar.

Kurzübersicht für Interleukin 17a Antikörper (Biotin) (ABIN2689740)

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Interleukin 17a Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Western Blotting (WB)

Klon: TC11

Produktdetails anti-Interleukin 17a Antikörper (Biotin)

Marke: BD Pharmingen™

Produktmerkmale: The TC11-8H4 monoclonal antibody specifically binds to recombinant and natural mouse IL-17A proteins. IL-17A, also known as Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8), is a T cell-derived cytokine that promotes inflammatory responses. Mouse IL-17A is a proinflammatory cytokine that can induce the release of IL-6 by mouse stromal cells. It has been shown to support the growth of hemopoietic progenitors in vitro, it can also stimulate granulopoiesis in vivo. Recent studies have shown that IL-17A is produced by a unique subset of Th17 cells that develop along a pathway distinct from the Th1- and Th2- cell differentiation pathways. The mouse IL-17A cDNA was isolated from a cDNA library generated from TCRαβ+CD4-CD8- thymocytes. Standard Curve Mouse IL-17A

BD Pharmingen™ Biotin Rat Anti-Mouse IL-17A - Biotin - Clone TC11-8H4 - Isotype Rat IgG1, κ - Reactivity Ms - 0.5 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Recombinant mouse IL-17A

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Referenzen für anti-Interleukin 17a Antikörper (Biotin) (ABIN2689740)

Dong: "Mouse Th17 cells: current understanding of their generation and regulation." in: European journal of immunology, Vol. 39, Issue 3, pp. 640-4, (2009) (PubMed).

Coquet, Chakravarti, Kyparissoudis, McNab, Pitt, McKenzie, Berzins, Smyth, Godfrey: "Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 32, pp. 11287-92, (2008) (PubMed).

Lampropoulou, Hoehlig, Roch, Neves, Calderón Gómez, Sweenie, Hao, Freitas, Steinhoff, Anderton, Fillatreau: "TLR-activated B cells suppress T cell-mediated autoimmunity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 7, pp. 4763-73, (2008) (PubMed).

Schwarzenberger, La Russa, Miller, Ye, Huang, Zieske, Nelson, Bagby, Stoltz, Mynatt, Spriggs, Kolls: "IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 11, pp. 6383-9, (1998) (PubMed).

Details zu Interleukin 17a

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Andere Bezeichnung: IL-17A

Hintergrund: Synonyms: IL-17, Il17, IL-17A, Il17a, CTLA-8, Ctla8, Interleukin-17A, interleukin 17A