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FOXP3 Antikörper

FOXP3 Reaktivität: Human, Pavian, Cynomolgus, Rhesusaffen WB, IHC, ICS Wirt: Maus Monoclonal 259D-C7 unconjugated
Produktnummer ABIN2689510
  • Target Alle FOXP3 Antikörper anzeigen
    FOXP3 (Forkhead Box P3 (FOXP3))
    Reaktivität
    • 164
    • 121
    • 51
    • 25
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Pavian, Cynomolgus, Rhesusaffen
    Wirt
    • 116
    • 67
    • 15
    • 2
    Maus
    Klonalität
    • 116
    • 84
    Monoklonal
    Konjugat
    • 91
    • 18
    • 13
    • 12
    • 12
    • 7
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Dieser FOXP3 Antikörper ist unkonjugiert
    Applikation
    • 134
    • 95
    • 70
    • 39
    • 37
    • 27
    • 27
    • 19
    • 18
    • 17
    • 9
    • 8
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Intracellular Staining (ICS)
    Marke
    BD Pharmingen™
    Produktmerkmale
    The 259D/C7 antibody reacts with the human FoxP3 transcription factor, a member of the forkhead or winged helix family of transcription factors. The expression of FoxP3, also known as Scurfin, IPEX and JM2, has been found to be associated with CD4+ regulatory T cells and represents a specific marker for these cells. Flow-cytometric analysis has shown that FoxP3 is expressed by the majority of CD4+CD25+high T cells in peripheral blood while less than half of CD4+CD25int cell population are FoxP3 positive. Approximately 5-10 % of peripheral CD4+ cells are CD4+CD25+ T regulatory cells. T regulatory cells are thought to play a critical role in the control of T cell mediated autoimmunity by suppressing the proliferation and cytokine production of other T cells. To support this hypothesis, it has been found that FOXP3 is mutated in scurfy (sf) mice. The 259D/C7 antibody reacts with all currently identified isoforms of human FoxP3 and is cross-reactive with Cynomolgus, Rhesus and Baboon. Flow cytometric analysis of Purified anti-Human FoxP3 on resting PBMC. Human PBMC were fixed and permeabilized using working solutions of FoxP3 Buffers A and C (Cat. No. 560098. see Recommended Assay Procedure), Intracellular staining with Purified Mouse anti-Human FoxP3 (clone 259D/C7, Cat. No. 560044) was followed by secondary staining with APC Rat anti-Mouse IgG1 (

    BD Pharmingen™ Purified Mouse anti-Human FoxP3 - Purified - Clone 259D/C7 - Isotype Mouse IgG1 - Reactivity Hu, Bab, Cyno, Rhe - 0.1 mg
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    FoxP3 recombinant protein
    Klon
    259D-C7
    Isotyp
    IgG1
    Top Product
    Discover our top product FOXP3 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4°C.
  • Roncador, Brown, Maestre, Hue, Martínez-Torrecuadrada, Ling, Pratap, Toms, Fox, Cerundolo, Powrie, Banham: "Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level." in: European journal of immunology, Vol. 35, Issue 6, pp. 1681-91, (2005) (PubMed).

    Brunkow, Jeffery, Hjerrild, Paeper, Clark, Yasayko, Wilkinson, Galas, Ziegler, Ramsdell: "Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse." in: Nature genetics, Vol. 27, Issue 1, pp. 68-73, (2001) (PubMed).

    Wildin, Ramsdell, Peake, Faravelli, Casanova, Buist, Levy-Lahad, Mazzella, Goulet, Perroni, Bricarelli, Byrne, McEuen, Proll, Appleby, Brunkow: "X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy." in: Nature genetics, Vol. 27, Issue 1, pp. 18-20, (2001) (PubMed).

  • Target
    FOXP3 (Forkhead Box P3 (FOXP3))
    Andere Bezeichnung
    FoxP3 (FOXP3 Produkte)
    Synonyme
    foxp3 antikoerper, FOXP3 antikoerper, AIID antikoerper, DIETER antikoerper, IPEX antikoerper, PIDX antikoerper, XPID antikoerper, JM2 antikoerper, scurfin antikoerper, sf antikoerper, RGD1562112 antikoerper, forkhead box P3 antikoerper, forkhead box P3a antikoerper, forkhead box P3 L homeolog antikoerper, FOXP3 antikoerper, foxp3a antikoerper, foxp3 antikoerper, foxp3.L antikoerper, Foxp3 antikoerper
    Hintergrund
    Synonyms: Scurfin, IPEX, JM2
    Pathways
    Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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