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CD77 Antikörper

Der Maus Monoklonal Anti-CD77-Antikörper wurde für FACS validiert. Er ist geeignet, CD77 in Proben von Human zu detektieren. Es sind 3+ Publikationen verfügbar.
Produktnummer ABIN2689395

Kurzübersicht für CD77 Antikörper (ABIN2689395)

Target

CD77

Reaktivität

Human

Wirt

  • 4
  • 1
  • 1
Maus

Klonalität

  • 5
  • 1
Monoklonal

Konjugat

  • 3
  • 2
  • 1
Dieser CD77 Antikörper ist unkonjugiert

Applikation

  • 5
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS)

Klon

5B5
  • Marke

    BD Pharmingen™

    Produktmerkmale

    Reacts with CD77, a small neutral glycosphingolipid, 1 kDa, also referred to as globotriaosylceramide (Gb3). CD77 is expressed on a subset of germinal center B-lymphocytes and not on peripheral blood lymphocytes, bone marrow or spleen. It has been described as a receptor for Shiga Toxin, produced by Shigella dysenteriae, and Verotoxin 1 (VT1), produced by some strains of E. coli. CD19 has been reported as a ligand for CD77 and these interaction functions in adhesion and signal transduction at a specific stage of B cell development. Studies have shown that cross-linking CD77 induces apoptosis in some B cell lines. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of Ramos cell line analyzed by flow cytometry. Second step staining with Cat. No. 555988.

    BD Pharmingen™ Purified Mouse Anti-Human CD77 - Purified - Clone 5B5 - Isotype Mouse IgM, κ - Reactivity Hu - 0.1 mg

    Aufreinigung

    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

    Isotyp

    IgM kappa
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    0.5 mg/mL

    Buffer

    Aqueous buffered solution containing ≤0.09 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store undiluted at 4°C.
  • Lagresle, Bella, Daniel, Krammer, Defrance: "Regulation of germinal center B cell differentiation. Role of the human APO-1/Fas (CD95) molecule." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 11, pp. 5746-56, (1995) (PubMed).

    Mangeney, Rousselet, Taga, Tursz, Wiels: "The fate of human CD77+ germinal center B lymphocytes after rescue from apoptosis." in: Molecular immunology, Vol. 32, Issue 5, pp. 333-9, (1995) (PubMed).

    Fyfe, Cebra-Thomas, Mustain, Davie, Alley, Nahm: "Subpopulations of B lymphocytes in germinal centers." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 139, Issue 7, pp. 2187-94, (1987) (PubMed).

  • Target

    CD77
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